FMNL1

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq]

Full Name

formin-like 1

Function

May play a role in the control of cell motility and survival of macrophages (By similarity).

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.

Biological Process

Actin filament severing Source: UniProtKB
Cell migration Source: GO_Central
Cortical actin cytoskeleton organization Source: UniProtKB
Regulation of cell shape Source: UniProtKB

Cellular Location

Cell membrane; Cytoplasm; Phagosome. Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity).
Isoform 3: Cell cortex; Bleb. Colocalized with F-actin in bleb protrusions.

PTM

Myristoylation mediates membrane localization and blebbing.

Anti-FMNL1 antibodies

Mouse Anti-FMNL1 Recombinant Antibody (CBXF-0770) (CBMAB-F2403-CQ)

Datasheet

SDS

Target: FMNL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-0770

Application*: WB

Mouse Anti-FMNL1 Recombinant Antibody (CBXF-3100) (CBMAB-F3796-CQ)

Datasheet

SDS

Target: FMNL1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXF-3100

Application*: E, WB

Mouse Anti-FMNL1 Recombinant Antibody (CBXF-3101) (CBMAB-F3797-CQ)

Datasheet

SDS

Target: FMNL1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-3101

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)