Sign in or Register

MAGEA3

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
Full Name
MAGE Family Member A3
Function
Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy (PubMed:20864041, PubMed:31267705).
May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:17942928, PubMed:20864041).
May play a role in embryonal development and tumor transformation or aspects of tumor progression (PubMed:17942928, PubMed:20864041).
In vitro promotes cell viability in melanoma cell lines (PubMed:17942928).
Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes (PubMed:8113684).
Biological Process
Negative regulation of autophagyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Negative regulation of protein processingManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum
Nucleus
PTM
Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation.
View more

Anti-MAGEA3 antibodies

+ Filters
Loading...

Mouse Anti-MAGEA3 Recombinant Antibody (CF274) (CBMAB-FT232LY)

Go to compareCompare
Target: MAGEA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CF274
Application*: ELISA, WB, IHC
Datasheet SDS

Mouse Anti-MAGEA3 Recombinant Antibody (CBFYM-1310) (CBMAB-M1469-FY)

Go to compareCompare
Target: MAGEA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Pig, Rat
Clone: CBFYM-1310
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-MAGEA3 Recombinant Antibody (A977) (CBMAB-AP11578LY)

Go to compareCompare
Target: MAGEA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: A977
Application*: ELISA, IHC, WB
Datasheet SDS

Rabbit Anti-MAGEA3 Recombinant Antibody (E9S4X) (CBMAB-CP1432-LY)

Go to compareCompare
Target: MAGEA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E9S4X
Application*: WB, IP
Datasheet SDS

Mouse Anti-MAGEA3 Recombinant Antibody (6D10) (CBMAB-A5159-LY)

Go to compareCompare
Target: MAGEA3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6D10
Application*: WB, E
Datasheet SDS

Mouse Anti-MAGEA3 Recombinant Antibody (4D9) (CBMAB-A5158-LY)

Go to compareCompare
Target: MAGEA3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4D9
Application*: WB, E
Datasheet SDS

Mouse Anti-MAGEA3 Recombinant Antibody (CBFYM-1309) (CBMAB-M1468-FY)

Go to compareCompare
Target: MAGEA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1309
Application*: E
Datasheet SDS

Mouse Anti-MAGEA3 (AA 44-114) Recombinant Antibody (CBFYM-1308) (CBMAB-M1467-FY)

Go to compareCompare
Target: MAGEA3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1308
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-MAGEA3 Recombinant Antibody (CBFYM-1307) (CBMAB-M1466-FY)

Go to compareCompare
Target: MAGEA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-1307
Application*: WB, IH
Datasheet SDS

Mouse Anti-MAGEA3 Recombinant Antibody (CBT4531) (V2LY-0625-LY1658)

Go to compareCompare
Target: MAGEA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4531
Application*: IC, F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry