A2M

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Full Name
Alpha-2-Macroglobulin
Function
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Biological Process
Extracellular matrix disassembly
Negative regulation of blood coagulation, intrinsic pathway
Negative regulation of complement activation, lectin pathway
Platelet degranulation
Regulation of small GTPase mediated signal transduction
Stem cell differentiation
Cellular Location
Secreted
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Anti-A2M antibodies

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Mouse Anti-A2M Recombinant Antibody (V2-178833) (CBMAB-A0048-YC)

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Target: A2M
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Rat
Clone: V2-178833
Application*: WB, IC, P, C, E, IP, IF, F
Datasheet SDS

Mouse Anti-A2M Recombinant Antibody (V2-178822) (CBMAB-A0036-YC)

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Target: A2M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-178822
Application*: E, WB
Datasheet SDS

Rabbit Anti-A2M Recombinant Antibody (V2-178837) (CBMAB-A0052-YC)

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Target: A2M
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-178837
Application*: WB, IC, IF
Datasheet SDS

Mouse Anti-A2M Recombinant Antibody (V2-178831) (CBMAB-A0046-YC)

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Target: A2M
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-178831
Application*: E, IP
Datasheet SDS

Mouse Anti-A2M Recombinant Antibody (V2-178828) (CBMAB-A0043-YC)

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Target: A2M
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Goat
Clone: V2-178828
Application*: WB, IP
Datasheet SDS

Mouse Anti-A2M Recombinant Antibody (V2-178827) (CBMAB-A0042-YC)

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Target: A2M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-178827
Application*: WB
Datasheet SDS

Mouse Anti-A2M Recombinant Antibody (V2-178826) (CBMAB-A0041-YC)

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Target: A2M
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-178826
Application*: E, WB, IP, IH, IF
Datasheet SDS

Mouse Anti-A2M Recombinant Antibody (V2-178823) (CBMAB-A0038-YC)

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Target: A2M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-178823
Application*: R, E
Datasheet SDS

Mouse Anti-A2M Recombinant Antibody (V2-178821) (CBMAB-A0035-YC)

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Target: A2M
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-178821
Application*: E, PLA, WB
Datasheet SDS

Mouse Anti-A2M Recombinant Antibody (V2-178819) (CBMAB-A0032-YC)

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Target: A2M
Host: Mouse
Antibody Isotype: IgM
Specificity: Mouse
Clone: V2-178819
Application*: E, WB
Datasheet SDS

Mouse Anti-A2M Recombinant Antibody (V2-178818) (CBMAB-A0031-YC)

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Target: A2M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-178818
Application*: WB
Datasheet SDS

Rabbit Anti-A2M Recombinant Antibody (V2-178817) (CBMAB-A0030-YC)

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Target: A2M
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-178817
Application*: E
Datasheet SDS

Mouse Anti-A2M Recombinant Antibody (V2-12482) (CBMAB-0972-CN)

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Target: A2M
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-12482
Application*: WB, IH, IC, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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