ADCY10

ADCY10 belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hyperc

Full Name

Adenylate Cyclase 10

Function

Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO2 levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation.

Biological Process

cAMP biosynthetic process
Cellular response to inorganic substance
Epithelial cilium movement involved in extracellular fluid movement
Intracellular signal transduction
Positive regulation of apoptotic process
Spermatogenesis

Cellular Location

Mitochondrion; Cytoplasm; Nucleus; Cytoskeleton; Cell membrane; Perinuclear region; Cilium. Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.

Involvement in disease

Hypercalciuria absorptive 2 (HCA2): A common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis.