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Mouse Anti-ADCY10 Recombinant Antibody (V2-179864) (CBMAB-A1241-YC)

Provided herein is a Mouse monoclonal antibody against Human Adenylate Cyclase 10. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all ADCY10 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
V2-179864
Antibody Isotype
IgM
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Specific for an epitope mapping between amino acids 1328-1346 within an internal region of A cyclase X of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate).
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.1% gelatin.
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adenylate Cyclase 10
Introduction
ADCY10 belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hyperc
Entrez Gene ID
Human55811
Mouse271639
Rat59320
UniProt ID
HumanQ96PN6
MouseQ8C0T9
RatQ9Z286
Alternative Names
Adenylate Cyclase 10; Germ Cell Soluble Adenylyl Cyclase; Adenylate Cyclase 10, Soluble; AH-Related Protein; EC 4.6.1.1; HsAC; SAC; Epididymis Secretory Sperm Binding Protein Li 7a; Testicular Soluble Adenylyl Cyclase (SAC); Testicular Soluble Adenylyl Cy
Function
Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO2 levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation.
Biological Process
cAMP biosynthetic process
Cellular response to inorganic substance
Epithelial cilium movement involved in extracellular fluid movement
Intracellular signal transduction
Positive regulation of apoptotic process
Spermatogenesis
Cellular Location
Mitochondrion; Cytoplasm; Nucleus; Cytoskeleton; Cell membrane; Perinuclear region; Cilium. Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.
Involvement in disease
Hypercalciuria absorptive 2 (HCA2): A common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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