ADGRB2

This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Full Name

Adhesion G Protein-Coupled Receptor B2

Function

Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity).

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Calcineurin-NFAT signaling cascade
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Negative regulation of angiogenesis
Peripheral nervous system development

Cellular Location

Cell membrane

Topology

Extracellular: 33-936 aa
Helical: 937-957 aa
Cytoplasmic: 958-965 aa
Helical: 966-986 aa
Extracellular: 987-994 aa
Helical: 995-1015 aa
Cytoplasmic: 1016-1036 aa
Helical: 1037-1057 aa
Extracellular: 1058-1078 aa
Helical: 1079-1099 aa
Cytoplasmic: 1100-1121 aa
Helical: 1122-1142 aa
Extracellular: 1143-1153 aa
Helical: 1154-1174 aa
Cytoplasmic: 1175-1585 aa

PTM

Autoproteolytic processes at the GPS domain; this cleavage modulates receptor activity. Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment.
Glycosylated.

Anti-ADGRB2 antibodies

Mouse Anti-ADGRB2 Recombinant Antibody (V2-12524) (CBMAB-1014-CN)

Datasheet

SDS

Target: ADGRB2

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: V2-12524

Application*: WB, E

Mouse Anti-ADGRB2 Recombinant Antibody (V2-611530) (CBMAB-A0702-LY)

Datasheet

SDS

Target: ADGRB2

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: V2-611530

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)