ADGRB2

This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Full Name

Adhesion G Protein-Coupled Receptor B2

Function

Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity).

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Calcineurin-NFAT signaling cascade
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Negative regulation of angiogenesis
Peripheral nervous system development

Cellular Location

Cell membrane

Topology

Extracellular: 33-936 aa
Helical: 937-957 aa
Cytoplasmic: 958-965 aa
Helical: 966-986 aa
Extracellular: 987-994 aa
Helical: 995-1015 aa
Cytoplasmic: 1016-1036 aa
Helical: 1037-1057 aa
Extracellular: 1058-1078 aa
Helical: 1079-1099 aa
Cytoplasmic: 1100-1121 aa
Helical: 1122-1142 aa
Extracellular: 1143-1153 aa
Helical: 1154-1174 aa
Cytoplasmic: 1175-1585 aa

PTM

Autoproteolytic processes at the GPS domain; this cleavage modulates receptor activity. Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment.
Glycosylated.