Mouse Anti-ADGRB2 Recombinant Antibody (V2-611530) (CBMAB-A0702-LY)

Name: Mouse Anti-ADGRB2 Recombinant Antibody (V2-611530)
SKU: CBMAB-A0702-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-611530

Application

WB, ELISA

Immunogen

BAI2 (NP_001694, 22 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate).
ELISA	1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin.

Preservative

< 0.1% sodium azide

Concentration

0.1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Adhesion G Protein-Coupled Receptor B2

Introduction

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis. [provided by RefSeq]

Entrez Gene ID

576

UniProt ID

O60241

Function

Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity).

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Calcineurin-NFAT signaling cascade
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Negative regulation of angiogenesis
Peripheral nervous system development

Cellular Location

Cell membrane

Topology

Extracellular: 33-936 aa
Helical: 937-957 aa
Cytoplasmic: 958-965 aa
Helical: 966-986 aa
Extracellular: 987-994 aa
Helical: 995-1015 aa
Cytoplasmic: 1016-1036 aa
Helical: 1037-1057 aa
Extracellular: 1058-1078 aa
Helical: 1079-1099 aa
Cytoplasmic: 1100-1121 aa
Helical: 1122-1142 aa
Extracellular: 1143-1153 aa
Helical: 1154-1174 aa
Cytoplasmic: 1175-1585 aa

PTM

Autoproteolytic processes at the GPS domain; this cleavage modulates receptor activity. Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment.
Glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-ADGRB2 Recombinant Antibody (V2-12524) (CAT#: CBMAB-1014-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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