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Mouse Anti-ADGRB2 Recombinant Antibody (V2-12524) (CBMAB-1014-CN)

This product is a mouse antibody that recognizes ADGRB2 of human. The antibody 6A12 can be used for immunoassay techniques such as: WB, ELISA.
See all ADGRB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-12524
Antibody Isotype
IgG3
Application
WB, ELISA

Basic Information

Immunogen
BAI2 (NP_001694, aa. 22-108) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG3
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1x PBS,  pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adhesion G Protein-Coupled Receptor B2
Introduction
This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products. Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. This protein activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. It's also involved in angiogenesis inhibition.
Entrez Gene ID
576
UniProt ID
O60241
Alternative Names
BAI2
Function
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity).
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Calcineurin-NFAT signaling cascade
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Negative regulation of angiogenesis
Peripheral nervous system development
Cellular Location
Cell membrane
Topology
Extracellular: 33-936 aa
Helical: 937-957 aa
Cytoplasmic: 958-965 aa
Helical: 966-986 aa
Extracellular: 987-994 aa
Helical: 995-1015 aa
Cytoplasmic: 1016-1036 aa
Helical: 1037-1057 aa
Extracellular: 1058-1078 aa
Helical: 1079-1099 aa
Cytoplasmic: 1100-1121 aa
Helical: 1122-1142 aa
Extracellular: 1143-1153 aa
Helical: 1154-1174 aa
Cytoplasmic: 1175-1585 aa
PTM
Autoproteolytic processes at the GPS domain; this cleavage modulates receptor activity. Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment.
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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