ADGRE3

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Full Name

Adhesion G Protein-Coupled Receptor E3

Function

Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Neutrophil degranulation

Cellular Location

Cell membrane
Isoform 3: Secreted

Topology

Extracellular: 22-357 aa
Helical: 358-378 aa
Cytoplasmic: 379-389 aa
Helical: 390-410 aa
Extracellular: 411-416 aa
Helical: 417-437 aa
Cytoplasmic: 438-464 aa
Helical: 465-485 aa
Extracellular: 486-508 aa
Helical: 509-529 aa
Cytoplasmic: 530-557 aa
Helical: 558-578 aa
Extracellular: 579-580 aa
Helical: 581-601 aa
Cytoplasmic: 602-652 aa

PTM

Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.