ADGRL3

ADGRL3 is a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich G

Full Name

Adhesion G Protein-Coupled Receptor L3

Function

Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Brain development
Cell-cell adhesion via plasma-membrane adhesion molecules
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Neuron migration
Synapse assembly

Cellular Location

Cell membrane; Axon

Topology

Extracellular: 20-866 aa
Helical: 867-889 aa
Cytoplasmic: 890-901 aa
Helical: 902-919 aa
Extracellular: 920-933 aa
Helical: 934-956 aa
Cytoplasmic: 957-968 aa
Helical: 969-988 aa
Extracellular: 989-1007 aa
Helical: 1008-1030 aa
Cytoplasmic: 1031-1049 aa
Helical: 1050-1072 aa
Extracellular: 1073-1081 aa
Helical: 1082-1104 aa
Cytoplasmic: 1105-1447 aa

PTM

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
O-glycosylated (major) and N-glycosylated.

Anti-ADGRL3 antibodies

Mouse Anti-ADGRL3 Recombinant Antibody (V2-58651) (CBMAB-L0302-YJ)

Datasheet

SDS

Target: ADGRL3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: V2-58651

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)