ADGRL3

ADGRL3 is a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich G

Full Name

Adhesion G Protein-Coupled Receptor L3

Function

Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Brain development
Cell-cell adhesion via plasma-membrane adhesion molecules
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Neuron migration
Synapse assembly

Cellular Location

Cell membrane; Axon

Topology

Extracellular: 20-866 aa
Helical: 867-889 aa
Cytoplasmic: 890-901 aa
Helical: 902-919 aa
Extracellular: 920-933 aa
Helical: 934-956 aa
Cytoplasmic: 957-968 aa
Helical: 969-988 aa
Extracellular: 989-1007 aa
Helical: 1008-1030 aa
Cytoplasmic: 1031-1049 aa
Helical: 1050-1072 aa
Extracellular: 1073-1081 aa
Helical: 1082-1104 aa
Cytoplasmic: 1105-1447 aa

PTM

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
O-glycosylated (major) and N-glycosylated.