Mouse Anti-ADGRL3 Recombinant Antibody (V2-58651) (CBMAB-L0302-YJ)

Name: Mouse Anti-ADGRL3 Recombinant Antibody (V2-58651)
SKU: CBMAB-L0302-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-58651

Application

ELISA, WB

Immunogen

Recombinant protein corresponding to aa1-813 from human LPHN3, CHO-derived (UniProt # Q9HAR2).

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	2 μg/ml
Simple Western	20 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-813

More Infomation

Target

Full Name

Adhesion G Protein-Coupled Receptor L3

Introduction

ADGRL3 is a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both signal transduction and cell adhesion. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain generated two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with extensive similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.

Entrez Gene ID

Human	23284
Mouse	319387
Rat	170641

UniProt ID

Human	Q9HAR2
Mouse	Q80TS3
Rat	Q9Z173

Alternative Names

Adhesion G Protein-Coupled Receptor L3; Calcium-Independent Alpha-Latrotoxin Receptor 3; Latrophilin-3; CIRL-3; LPHN3; LEC3; Latrophilin Homolog 3 (Cow)

Function

Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Brain development
Cell-cell adhesion via plasma-membrane adhesion molecules
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Neuron migration
Synapse assembly

Cellular Location

Cell membrane; Axon

Topology

Extracellular: 20-866 aa
Helical: 867-889 aa
Cytoplasmic: 890-901 aa
Helical: 902-919 aa
Extracellular: 920-933 aa
Helical: 934-956 aa
Cytoplasmic: 957-968 aa
Helical: 969-988 aa
Extracellular: 989-1007 aa
Helical: 1008-1030 aa
Cytoplasmic: 1031-1049 aa
Helical: 1050-1072 aa
Extracellular: 1073-1081 aa
Helical: 1082-1104 aa
Cytoplasmic: 1105-1447 aa

PTM

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
O-glycosylated (major) and N-glycosylated.

Chatterjee, M., Saha, S., Shom, S., Sinha, S., & Mukhopadhyay, K. (2021). Adhesion G protein-coupled receptor L3 gene variants: Statistically significant association observed in the male Indo-caucasoid Attention deficit hyperactivity disorder probands. Molecular Biology Reports, 1-10.

Moreno-Alcázar, A., Ramos-Quiroga, J. A., Ribases, M., Sánchez-Mora, C., Palomar, G., Bosch, R., ... & Radua, J. (2021). Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder. Scientific Reports, 11(1), 1-12.

Bruxel, E. M., Moreira-Maia, C. R., Akutagava-Martins, G. C., Quinn, T. P., Klein, M., Franke, B., ... & Hutz, M. H. (2020). Meta-analysis and systematic review of ADGRL3 (LPHN3) polymorphisms in ADHD susceptibility. Molecular psychiatry, 1-9.

Marquardt, S. A., Wilcox, C. V., Burns, E. N., Peterson, J. A., & Finno, C. J. (2019). Previously identified genetic variants in ADGRL3 are not associated with risk for equine degenerative myeloencephalopathy across breeds. Genes, 10(9), 681.

Mortimer, N., Ganster, T., O'Leary, A., Popp, S., Freudenberg, F., Reif, A., ... & Rivero, O. (2019). Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation. Neuropharmacology, 156, 107557.

Posbergh, C. J., Pollott, G. E., Southard, T. L., Divers, T. J., & Brooks, S. A. (2018). A Nonsynonymous Change in Adhesion G Protein–Coupled Receptor L3 Associated with Risk for Equine Degenerative Myeloencephalopathy in the Caspian Horse. Journal of Equine Veterinary Science, 70, 96-100.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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