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Mouse Anti-ADGRL3 Recombinant Antibody (V2-58651) (CBMAB-L0302-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Adhesion G Protein-Coupled Receptor L3 (ADGRL3). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all ADGRL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
V2-58651
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa1-813 from human LPHN3, CHO-derived (UniProt # Q9HAR2).
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB2 μg/ml
Simple Western20 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-813

Target

Full Name
Adhesion G Protein-Coupled Receptor L3
Introduction
ADGRL3 is a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both signal transduction and cell adhesion. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain generated two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with extensive similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.
Entrez Gene ID
Human23284
Mouse319387
Rat170641
UniProt ID
HumanQ9HAR2
MouseQ80TS3
RatQ9Z173
Alternative Names
Adhesion G Protein-Coupled Receptor L3; Calcium-Independent Alpha-Latrotoxin Receptor 3; Latrophilin-3; CIRL-3; LPHN3; LEC3; Latrophilin Homolog 3 (Cow)
Function
Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Brain development
Cell-cell adhesion via plasma-membrane adhesion molecules
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Neuron migration
Synapse assembly
Cellular Location
Cell membrane; Axon
Topology
Extracellular: 20-866 aa
Helical: 867-889 aa
Cytoplasmic: 890-901 aa
Helical: 902-919 aa
Extracellular: 920-933 aa
Helical: 934-956 aa
Cytoplasmic: 957-968 aa
Helical: 969-988 aa
Extracellular: 989-1007 aa
Helical: 1008-1030 aa
Cytoplasmic: 1031-1049 aa
Helical: 1050-1072 aa
Extracellular: 1073-1081 aa
Helical: 1082-1104 aa
Cytoplasmic: 1105-1447 aa
PTM
Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
O-glycosylated (major) and N-glycosylated.

Chatterjee, M., Saha, S., Shom, S., Sinha, S., & Mukhopadhyay, K. (2021). Adhesion G protein-coupled receptor L3 gene variants: Statistically significant association observed in the male Indo-caucasoid Attention deficit hyperactivity disorder probands. Molecular Biology Reports, 1-10.

Moreno-Alcázar, A., Ramos-Quiroga, J. A., Ribases, M., Sánchez-Mora, C., Palomar, G., Bosch, R., ... & Radua, J. (2021). Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder. Scientific Reports, 11(1), 1-12.

Bruxel, E. M., Moreira-Maia, C. R., Akutagava-Martins, G. C., Quinn, T. P., Klein, M., Franke, B., ... & Hutz, M. H. (2020). Meta-analysis and systematic review of ADGRL3 (LPHN3) polymorphisms in ADHD susceptibility. Molecular psychiatry, 1-9.

Marquardt, S. A., Wilcox, C. V., Burns, E. N., Peterson, J. A., & Finno, C. J. (2019). Previously identified genetic variants in ADGRL3 are not associated with risk for equine degenerative myeloencephalopathy across breeds. Genes, 10(9), 681.

Mortimer, N., Ganster, T., O'Leary, A., Popp, S., Freudenberg, F., Reif, A., ... & Rivero, O. (2019). Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation. Neuropharmacology, 156, 107557.

Posbergh, C. J., Pollott, G. E., Southard, T. L., Divers, T. J., & Brooks, S. A. (2018). A Nonsynonymous Change in Adhesion G Protein–Coupled Receptor L3 Associated with Risk for Equine Degenerative Myeloencephalopathy in the Caspian Horse. Journal of Equine Veterinary Science, 70, 96-100.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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