ADORA3

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

adenosine A3 receptor

Function

Isoform 2: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.

Biological Process

Activation of adenylate cyclase activity
G protein-coupled receptor signaling pathway
Inflammatory response
Negative regulation of cell migration
Negative regulation of cell population proliferation
Negative regulation of NF-kappaB transcription factor activity
Regulation of heart contraction
Response to wounding
Signal transduction

Cellular Location

Cell membrane

Topology

Extracellular: 1-14 aa
Helical: 15-37 aa
Cytoplasmic: 38-48 aa
Helical: 49-72 aa
Extracellular: 73-84 aa
Helical: 85-106 aa
Cytoplasmic: 107-126 aa
Helical: 127-148 aa
Extracellular: 149-177 aa
Helical: 178-198 aa
Cytoplasmic: 199-231 aa
Helical: 232-255 aa
Extracellular: 256-261 aa
Helical: 262-284 aa
Cytoplasmic: 285-318 aa