AFG1L

AFG1L is a mitochondrial integral membrane protein that participate in mitochondrial protein homeostasis. AFG1L contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor binding sites are located within 2. 5 kb of this gene. Alternative splicing results in multiple transcript variants.

Full Name

AFG1 Like ATPase

Function

Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.

Biological Process

Mitochondrial electron transport, cytochrome c to oxygen
Mitochondrial protein catabolic process
Mitochondrion organization

Cellular Location

Mitochondrion membrane