AJUBA

Full Name

Ajuba LIM Protein

Function

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.

Biological Process

Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
Cellular protein localization Source: Ensembl
Cytoskeleton organization Source: GO_Central
Focal adhesion assembly Source: Ensembl
G2/M transition of mitotic cell cycle Source: Reactome
Gene silencing by miRNA Source: MGI
Glycerophospholipid biosynthetic process Source: Ensembl
Lamellipodium assembly Source: Ensembl
Negative regulation of hippo signaling Source: UniProtKB
Negative regulation of kinase activity Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of cellular biosynthetic process Source: Ensembl
Positive regulation of gene silencing by miRNA Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Positive regulation of MAP kinase activity Source: Ensembl
Positive regulation of protein-containing complex assembly Source: MGI
Regulation of cell migration Source: Ensembl
Regulation of cellular response to hypoxia Source: UniProtKB
Regulation of GTPase activity Source: Ensembl
Regulation of transcription, DNA-templated Source: GO_Central
Response to hypoxia Source: UniProtKB
Wound healing, spreading of epidermal cells Source: Ensembl

Cellular Location

Cell membrane; Cytoskeleton; Centrosome; Nucleus; Cell junction; P-body. Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus.

PTM

Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA.