AK9

The protein encoded by this gene catalyzes the interconversion of nucleosides, possessing both nucleoside monophosphate and diphosphate kinase activities. The encoded protein uses these interconversions to maintain nucleoside homeostasis. [provided by RefSeq, Jul 2016]

Full Name

Adenylate Kinase 9

Function

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP> UDP> ADP> GDP> TDP.

Biological Process

AMP phosphorylation Source: UniProtKB
ATP generation from ADP Source: UniProtKB
CDP phosphorylation Source: UniProtKB
CMP phosphorylation Source: UniProtKB
dADP phosphorylation Source: UniProtKB
dAMP phosphorylation Source: UniProtKB
dCDP phosphorylation Source: UniProtKB
dCMP phosphorylation Source: UniProtKB
dGDP phosphorylation Source: UniProtKB
GDP phosphorylation Source: UniProtKB
Nucleobase-containing small molecule interconversion Source: Reactome
TDP phosphorylation Source: UniProtKB
UDP phosphorylation Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm