AKTIP

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered p

Full Name

AKT Interacting Protein

Function

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.

Biological Process

Apoptotic process Source: UniProtKB-KW
Early endosome to late endosome transport Source: UniProtKB
Endosome organization Source: UniProtKB
Endosome to lysosome transport Source: UniProtKB
Lysosome organization Source: UniProtKB
Positive regulation of protein binding Source: MGI
Positive regulation of protein phosphorylation Source: MGI
Protein polyubiquitination Source: GO_Central
Protein transport

Cellular Location

Cell membrane; Cytoplasm

Anti-AKTIP antibodies

Mouse Anti-AKTIP Recombinant Antibody (V2-613690) (CBMAB-A3218-LY)

Datasheet

SDS

Target: AKTIP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-613690

Application*: WB, E

Mouse Anti-AKTIP Recombinant Antibody (V2-160821) (CBMAB-F0749-CQ)

Datasheet

SDS

Target: AKTIP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: V2-160821

Application*: WB, P, E

Mouse Anti-AKTIP Recombinant Antibody (V2-12570) (CBMAB-1060-CN)

Datasheet

SDS

Target: AKTIP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-12570

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)