Mouse Anti-AKTIP Recombinant Antibody (V2-12570) (CBMAB-1060-CN)

Name: Mouse Anti-AKTIP Recombinant Antibody (V2-12570)
SKU: CBMAB-1060-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-12570

Application

WB, ELISA

Immunogen

FTS (AAH01134, aa. 1-292) full-length recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

AKT Interacting Protein

Introduction

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. This protein is a component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). It regulates apoptosis by enhancing phosphorylation and activation of AKT1 and increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.

Entrez Gene ID

64400

UniProt ID

Q9H8T0

Alternative Names

FT1; FTS

Function

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.

Biological Process

Apoptotic process Source: UniProtKB-KW
Early endosome to late endosome transport Source: UniProtKB
Endosome organization Source: UniProtKB
Endosome to lysosome transport Source: UniProtKB
Lysosome organization Source: UniProtKB
Positive regulation of protein binding Source: MGI
Positive regulation of protein phosphorylation Source: MGI
Protein polyubiquitination Source: GO_Central
Protein transport

Cellular Location

Cell membrane; Cytoplasm

Khalil, M. I., Madere, C., Ghosh, I., Adam, R. M., & De Benedetti, A. (2021). Interaction of TLK1 and AKTIP as a Potential Regulator of AKT Activation in Castration-Resistant Prostate Cancer Progression. Pathophysiology, 28(3), 339-354.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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