APOL1

This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Full Name
Apolipoprotein L1
Function
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
Biological Process
Cellular protein metabolic process Source: Reactome
Chloride transmembrane transport Source: BHF-UCL
Cholesterol metabolic process Source: UniProtKB-KW
Cytolysis by host of symbiont cells Source: BHF-UCL
Innate immune response Source: BHF-UCL
Lipid transport Source: UniProtKB-KW
Lipoprotein metabolic process Source: InterPro
Post-translational protein modification Source: Reactome
Receptor-mediated endocytosis Source: Reactome
Cellular Location
Secreted
Involvement in disease
Focal segmental glomerulosclerosis 4 (FSGS4): A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
PTM
Phosphorylated by FAM20C in the extracellular medium.
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Anti-APOL1 antibodies

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Human Recombinant APOL1 protein, His Tag-1 (V2LY-0526-LY2143)

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Target: APOL1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-398
Tag: His Tag
Datasheet SDS

Human Recombinant APOL1 protein, His Tag (V2LY-0526-LY2142)

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Target: APOL1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-398
Tag: His Tag
Datasheet SDS

Rabbit Anti-APOL1 Recombinant Antibody (
32H8) (V2LY-0725-LY1547)

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Target: APOL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 32H8
Application*: E, F
Datasheet SDS

Mouse Anti-APOL1 Recombinant Antibody (CBT173) (V2LY-0625-LY3740)

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Target: APOL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT173
Application*: WB, E
Datasheet SDS

Mouse Anti-APOL1 Recombinant Antibody (CBT4221) (V2LY-0625-LY2255)

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Target: APOL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4221
Application*: WB
Datasheet SDS

Mouse Anti-APOL1 Recombinant Antibody (1G12D11) (CBMAB-A3259-YC)

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Target: APOL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G12D11
Application*: WB, IP, IH, IF, FC
Datasheet SDS

Mouse Anti-APOL1 Recombinant Antibody (1D4) (CBMAB-A3258-YC)

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Target: APOL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D4
Application*: WB, E
Datasheet SDS

Mouse Anti-APOL1 Recombinant Antibody (13B41) (CBMAB-A3257-YC)

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Target: APOL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 13B41
Application*: E, IF, WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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