AQP1

This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement. [provided by RefSeq, Aug 2016]

Full Name

Aquaporin 1 (Colton Blood Group)

Function

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

Biological Process

Ammonium transport Source: UniProtKB
Bicarbonate transport Source: Reactome
Carbon dioxide transmembrane transport Source: UniProtKB
Carbon dioxide transport Source: UniProtKB
Cellular homeostasis Source: UniProtKB
Cellular hyperosmotic response Source: UniProtKB
Cellular response to cAMP Source: UniProtKB
Cellular response to copper ion Source: UniProtKB
Cellular response to dexamethasone stimulus Source: UniProtKB
Cellular response to hydrogen peroxide Source: UniProtKB
Cellular response to hypoxia Source: UniProtKB
Cellular response to inorganic substance Source: UniProtKB
Cellular response to mechanical stimulus Source: UniProtKB
Cellular response to mercury ion Source: UniProtKB
Cellular response to nitric oxide Source: UniProtKB
Cellular response to retinoic acid Source: UniProtKB
Cellular response to salt stress Source: UniProtKB
Cellular response to UV Source: UniProtKB
Cellular water homeostasis Source: UniProtKB
Cell volume homeostasis Source: UniProtKB
Cerebrospinal fluid secretion Source: UniProtKB
cGMP-mediated signaling Source: UniProtKB
Defense response to Gram-negative bacterium Source: UniProtKB
Establishment or maintenance of actin cytoskeleton polarity Source: UniProtKB
Glycerol transport Source: UniProtKB
Hyperosmotic response Source: GO_Central
Lateral ventricle development Source: UniProtKB
Maintenance of symbiont-containing vacuole by host Source: UniProtKB
Multicellular organismal water homeostasis Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Nitric oxide transport Source: UniProtKB
Odontogenesis Source: UniProtKB
Pancreatic juice secretion Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of fibroblast proliferation Source: UniProtKB
Positive regulation of saliva secretion Source: UniProtKB
Potassium ion transport Source: UniProtKB
Renal water homeostasis Source: Reactome
Renal water transport Source: UniProtKB
Transepithelial water transport Source: UniProtKB
Water transport Source: UniProtKB

Cellular Location

Cell membrane

Topology

Cytoplasmic: 2-7 aa
Helical: 8-36 aa
Extracellular: 37-48 aa
Helical: 49-66 aa
Cytoplasmic: 67-70 aa
Helical: 71-84 aa
Cytoplasmic: 85-94 aa
Helical: 95-115 aa
Extracellular: 116-136 aa
Helical: 137-155 aa
Cytoplasmic: 156-166 aa
Helical: 167-183 aa
Extracellular: 184-186 aa
Helical: 187-200 aa
Extracellular: 201-207 aa
Helical: 208-228 aa
Cytoplasmic: 229-269 aa