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Mouse Anti-AQP1 Recombinant Antibody (1/A5F6) (CBMAB-A3349-YC)

Provided herein is a Mouse monoclonal antibody against Human Aquaporin 1 (Colton Blood Group). The antibody can be used for immunoassay techniques, such as ELISA, IHC, IHC-Fr, IHC-P, WB.
See all AQP1 antibodies
Published Data
Fig.1 Confocal images of Strawberry expression in renal sections of ELS infected kidneys 60 days post injection.
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Fig.2 AQP1 and AQP4 detection on Hep-G2 cells with FITC labelled anti-AQP1 and anti-AQP4 monoclonal antibodies.
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Fig.3 Western Blot analysis of AQP1 and AQP4 molecules in the membrane fraction.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Rabbit
Clone
1/A5F6
Antibody Isotype
IgG1
Application
ELISA, IHC, IHC-P, WB

Basic Information

Immunogen
Synthetic peptide corresponding to amino acids 249-269 of aquaporin 1.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Rabbit
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000-1:5,000
IHC1:500-1:1,000
ELISA1:1,000-1:20,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA
Preservative
< 0.1% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aquaporin 1 (Colton Blood Group)
Introduction
AQP1 is a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imb
Entrez Gene ID
Human358
Mouse11826
Rat25240
Zebrafish553476
Rabbit100008839
UniProt ID
HumanP29972
MouseQ02013
RatP29975
RabbitQ5XPM0
Alternative Names
Aquaporin 1 (Colton Blood Group); Aquaporin 1 (Channel-Forming Integral Protein, 28kDa, CO Blood Group); Water Channel Protein For Red Blood Cells And Kidney Proximal Tubule; Urine Water Channel; Aquaporin-CHIP; CHIP28; Aquaporin 1 (Channel-Forming Integr
Function
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Biological Process
Ammonium transport Source: UniProtKB
Bicarbonate transport Source: Reactome
Carbon dioxide transmembrane transport Source: UniProtKB
Carbon dioxide transport Source: UniProtKB
Cellular homeostasis Source: UniProtKB
Cellular hyperosmotic response Source: UniProtKB
Cellular response to cAMP Source: UniProtKB
Cellular response to copper ion Source: UniProtKB
Cellular response to dexamethasone stimulus Source: UniProtKB
Cellular response to hydrogen peroxide Source: UniProtKB
Cellular response to hypoxia Source: UniProtKB
Cellular response to inorganic substance Source: UniProtKB
Cellular response to mechanical stimulus Source: UniProtKB
Cellular response to mercury ion Source: UniProtKB
Cellular response to nitric oxide Source: UniProtKB
Cellular response to retinoic acid Source: UniProtKB
Cellular response to salt stress Source: UniProtKB
Cellular response to UV Source: UniProtKB
Cellular water homeostasis Source: UniProtKB
Cell volume homeostasis Source: UniProtKB
Cerebrospinal fluid secretion Source: UniProtKB
cGMP-mediated signaling Source: UniProtKB
Defense response to Gram-negative bacterium Source: UniProtKB
Establishment or maintenance of actin cytoskeleton polarity Source: UniProtKB
Glycerol transport Source: UniProtKB
Hyperosmotic response Source: GO_Central
Lateral ventricle development Source: UniProtKB
Maintenance of symbiont-containing vacuole by host Source: UniProtKB
Multicellular organismal water homeostasis Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Nitric oxide transport Source: UniProtKB
Odontogenesis Source: UniProtKB
Pancreatic juice secretion Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of fibroblast proliferation Source: UniProtKB
Positive regulation of saliva secretion Source: UniProtKB
Potassium ion transport Source: UniProtKB
Renal water homeostasis Source: Reactome
Renal water transport Source: UniProtKB
Transepithelial water transport Source: UniProtKB
Water transport Source: UniProtKB
Cellular Location
Cell membrane
Topology
Cytoplasmic: 2-7 aa
Helical: 8-36 aa
Extracellular: 37-48 aa
Helical: 49-66 aa
Cytoplasmic: 67-70 aa
Helical: 71-84 aa
Cytoplasmic: 85-94 aa
Helical: 95-115 aa
Extracellular: 116-136 aa
Helical: 137-155 aa
Cytoplasmic: 156-166 aa
Helical: 167-183 aa
Extracellular: 184-186 aa
Helical: 187-200 aa
Extracellular: 201-207 aa
Helical: 208-228 aa
Cytoplasmic: 229-269 aa

Chong, W., Zhang, H., Guo, Z., Yang, L., Shao, Y., Liu, X., ... & Gu, F. (2021). Aquaporin 1 promotes sensitivity of anthracycline chemotherapy in breast cancer by inhibiting β-catenin degradation to enhance TopoIIα activity. Cell Death & Differentiation, 28(1), 382-400.

Lamagna, B., Ciaramella, P., Lamagna, F., Di Loria, A., Brunetti, A., & Pelagalli, A. (2020). Aquaporin 1 (AQP1) expression in healthy dog tears. Animals, 10(5), 820.

Maltaneri, R. E., Schiappacasse, A., Chamorro, M. E., Nesse, A. B., & Vittori, D. C. (2020). Aquaporin-1 plays a key role in erythropoietin-induced endothelial cell migration. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1867(1), 118569.

Montiel, V., Bella, R., Michel, L. Y., Esfahani, H., De Mulder, D., Robinson, E. L., ... & Balligand, J. L. (2020). Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. Science translational medicine, 12(564).

Mu, Y. R., Zhou, M. Y., Cai, L., Liu, M. M., & Li, R. (2020). Overexpression of aquaporin 1 in synovium aggravates rat collagen-induced arthritis through regulating β-Catenin signaling: an in vivo and in vitro study. Journal of Inflammation Research, 13, 701.

Rivera, M. A., & Fahey, T. D. (2019). Association between aquaporin-1 and endurance performance: a systematic review. Sports medicine-open, 5(1), 1-12.

Yamazato, Y., Shiozaki, A., Ichikawa, D., Kosuga, T., Shoda, K., Arita, T., ... & Otsuji, E. (2018). Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma. Oncotarget, 9(52), 29957.

Imaizumi, H., Ishibashi, K., Takenoshita, S., & Ishida, H. (2018). Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer. Oncology letters, 15(5), 6450-6456.

Tomita, Y., Dorward, H., Yool, A. J., Smith, E., Townsend, A. R., Price, T. J., & Hardingham, J. E. (2017). Role of aquaporin 1 signalling in cancer development and progression. International journal of molecular sciences, 18(2), 299.

Yun, X., Jiang, H., Lai, N., Wang, J., & Shimoda, L. A. (2017). Aquaporin 1-mediated changes in pulmonary arterial smooth muscle cell migration and proliferation involve β-catenin. American Journal of Physiology-Lung Cellular and Molecular Physiology, 313(5), L889-L898.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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