ARHGAP42

This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]

Rho GTPase Activating Protein 42

May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.

Activation of GTPase activity Source: UniProtKB
Negative regulation of Rho protein signal transduction Source: Ensembl
Negative regulation of systemic arterial blood pressure Source: Ensembl
Negative regulation of vascular associated smooth muscle contraction Source: Ensembl
Signal transduction Source: InterPro