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ARHGAP42

This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]

Full Name

Rho GTPase Activating Protein 42

Function

May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.

Biological Process

Activation of GTPase activity Source: UniProtKB
Negative regulation of Rho protein signal transduction Source: Ensembl
Negative regulation of systemic arterial blood pressure Source: Ensembl
Negative regulation of vascular associated smooth muscle contraction Source: Ensembl
Signal transduction Source: InterPro

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Anti-ARHGAP42 antibodies

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Rabbit Anti-ARHGAP42 (Phosphorylated Y376) Recombinant Antibody (D45E9) (PTM-CBMAB-0044YC)

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Target: ARHGAP42

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Monkey

Clone: D45E9

Application*: WB, IP

Mouse Anti-ARHGAP42 Recombinant Antibody (CBT3338) (V2LY-0625-LY625)

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Target: ARHGAP42

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3338

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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