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Mouse Anti-ARHGAP42 Recombinant Antibody (CBT3338) (V2LY-0625-LY625)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3338
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human ARHGAP42 (AA: 577-719) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Rho GTPase Activating Protein 42
Entrez Gene ID
143872
UniProt ID
A6NI28
Function
May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.
Biological Process
Activation of GTPase activity Source: UniProtKB
Negative regulation of Rho protein signal transduction Source: Ensembl
Negative regulation of systemic arterial blood pressure Source: Ensembl
Negative regulation of vascular associated smooth muscle contraction Source: Ensembl
Signal transduction Source: InterPro
More Infomation

Li, Q., Dibus, M., Casey, A., Yee, C. S., Vargas, S. O., Luo, S., ... & Agrawal, P. B. (2021). A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings. PLoS genetics, 17(7), e1009639.

Mangum, K. D., Freeman, E. J., Magin, J. C., Taylor, J. M., & Mack, C. P. (2020). Transcriptional and posttranscriptional regulation of the SMC-selective blood pressure-associated gene, ARHGAP42. American Journal of Physiology-Heart and Circulatory Physiology, 318(2), H413-H424.

Fjorder, A. S., Rasmussen, M. B., Mehrjouy, M. M., Nazaryan-Petersen, L., Hansen, C., Bak, M., ... & Bache, I. (2019). Haploinsufficiency of ARHGAP42 is associated with hypertension. European Journal of Human Genetics, 27(8), 1296-1303.

Hu, Q., Lin, X., Ding, L., Zeng, Y., Pang, D., Ouyang, N., ... & Yao, H. (2018). ARHGAP 42 promotes cell migration and invasion involving PI 3K/Akt signaling pathway in nasopharyngeal carcinoma. Cancer medicine, 7(8), 3862-3874.

Luo, W., Janoštiak, R., Tolde, O., Ryzhova, L. M., Koudelková, L., Dibus, M., ... & Rosel, D. (2017). ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility. Journal of cell science, 130(14), 2382-2393.

Bai, X., Mangum, K. D., Dee, R. A., Stouffer, G. A., Lee, C. R., Oni-Orisan, A., ... & Mack, C. P. (2017). Blood pressure–associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. The Journal of clinical investigation, 127(2), 670-680.

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For research use only. Not intended for any clinical use.

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