ARID4A

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq]

Full Name

AT rich interactive domain 4A (RBP1-like)

Function

DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity).
May function as part of an mSin3A repressor complex (PubMed:14581478).
Has no intrinsic transcriptional activity (By similarity).
Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity).
Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity).
Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).

Biological Process

Erythrocyte development Source: Ensembl
Establishment of Sertoli cell barrier Source: Ensembl
Histone H3-K4 trimethylation Source: Ensembl
Histone H3-K9 trimethylation Source: Ensembl
Histone H4-K20 trimethylation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: GDB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of gene expression by genetic imprinting Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Spermatogenesis Source: UniProtKB-KW

Cellular Location

Nucleus