ATAD3B

ATAD3B is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expresse

Full Name

ATPase Family, AAA Domain Containing 3B

Function

May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.

Biological Process

Mitochondrion organization Source: GO_Central
Neutrophil degranulation Source: Reactome

Cellular Location

Mitochondrion inner membrane. Has been found to co-purify with nucleoids (PubMed:22453275). Since it does not face the mitochondrial matrix, the association with nucleoids could be mediated by ATAD3A.

Topology

Mitochondrial intermembrane: 2-246 aa
Helical: 247-264 aa
Mitochondrial intermembrane: 265-648 aa