ATP5IF1

ATP5IF1 is a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified.

Full Name

ATP Synthase Inhibitory Factor Subunit 1

Function

Endogenous F1F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F1F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F1F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.

Biological Process

Angiogenesis Source: UniProtKB
Erythrocyte differentiation Source: UniProtKB
Generation of precursor metabolites and energy Source: ProtInc
Heme biosynthetic process Source: UniProtKB
Mitochondrial depolarization Source: ParkinsonsUK-UCL
Negative regulation of ATPase activity Source: ParkinsonsUK-UCL
Negative regulation of endothelial cell proliferation Source: UniProtKB
Negative regulation of hydrolase activity Source: UniProtKB
Positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: Ensembl
Positive regulation of proteolysis involved in cellular protein catabolic process Source: ParkinsonsUK-UCL
Reactive oxygen species metabolic process Source: Ensembl
Regulation of ATP metabolic process Source: ParkinsonsUK-UCL
Regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL

Cellular Location

Mitochondrion

PTM

Exhibits variability in chain length, mitochondria have distinct pools of protein cleaved after the 24th, 25th, and 26th amino acid.