BCL9

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq]

Full Name

B-cell CLL/lymphoma 9

Function

Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).

Biological Process

Beta-catenin-TCF complex assembly Source: Reactome
Canonical Wnt signaling pathway Source: GO_Central
Myotube differentiation involved in skeletal muscle regeneration Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle cell differentiation Source: Ensembl
Somatic stem cell population maintenance Source: Ensembl

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving BCL9 is found in a patient with precursor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.

Anti-BCL9 antibodies

Mouse Anti-BCL9 Recombinant Antibody (CBYY-0452) (CBMAB-0455-YY)

Datasheet

SDS

Target: BCL9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-0452

Application*: WB, IF

Mouse Anti-BCL9 Recombinant Antibody (V2-611565) (CBMAB-A0745-LY)

Datasheet

SDS

Target: BCL9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-611565

Application*: WB, E

Mouse Anti-BCL9 Recombinant Antibody (CBYY-1990) (CBMAB-2339-YY)

Datasheet

SDS

Target: BCL9

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-1990

Application*: WB

Mouse Anti-BCL9 Recombinant Antibody (CBYY-1940) (CBMAB-2289-YY)

Datasheet

SDS

Target: BCL9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-1940

Application*: IP, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)