BCL9

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq]
Full Name
B-cell CLL/lymphoma 9
Function
Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).
Biological Process
Beta-catenin-TCF complex assembly Source: Reactome
Canonical Wnt signaling pathway Source: GO_Central
Myotube differentiation involved in skeletal muscle regeneration Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle cell differentiation Source: Ensembl
Somatic stem cell population maintenance Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving BCL9 is found in a patient with precursor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.
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Anti-BCL9 antibodies

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Mouse Anti-BCL9 Recombinant Antibody (V2-611565) (CBMAB-A0745-LY)

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Target: BCL9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-611565
Application*: WB, E
Datasheet SDS

Mouse Anti-BCL9 Recombinant Antibody (CBYY-1990) (CBMAB-2339-YY)

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Target: BCL9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1990
Application*: WB
Datasheet SDS

Mouse Anti-BCL9 Recombinant Antibody (CBYY-1940) (CBMAB-2289-YY)

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Target: BCL9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1940
Application*: IP, WB
Datasheet SDS

Mouse Anti-BCL9 Recombinant Antibody (CBYY-0452) (CBMAB-0455-YY)

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Target: BCL9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-0452
Application*: WB, IF
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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