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BDH2

Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).

Full Name

3-Hydroxybutyrate Dehydrogenase 2

Function

Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity).
Also acts as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372).

Biological Process

Epithelial cell differentiation Source: UniProtKB
Fatty acid beta-oxidation Source: HGNC-UCL
Heme metabolic process Source: UniProtKB
Iron ion homeostasis Source: UniProtKB
Ketone body biosynthetic process Source: Reactome
Siderophore biosynthetic process Source: UniProtKB

Cellular Location

Cytoplasm

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Anti-BDH2 antibodies

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Mouse Anti-BDH2 Recombinant Antibody (CBYY-2106) (CBMAB-2455-YY)

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Target: BDH2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBYY-2106

Application*: FC, IF, IH, WB

Mouse Anti-BDH2 Recombinant Antibody (CBYY-2059) (CBMAB-2408-YY)

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Target: BDH2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBYY-2059

Application*: FC, IF, IH, WB

Mouse Anti-BDH2 Recombinant Antibody (CBYY-1999) (CBMAB-2348-YY)

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Target: BDH2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYY-1999

Application*: WB, IH, IF, IP

Mouse Anti-BDH2 Recombinant Antibody (CBYY-0464) (CBMAB-0467-YY)

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Target: BDH2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat, Horse, Dog

Clone: CBYY-0464

Application*: WB, IH, IF, IP

Mouse Anti-BDH2 Recombinant Antibody (CBYY-0462) (CBMAB-0465-YY)

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Target: BDH2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat

Clone: CBYY-0462

Application*: WB, IH, IF, IP

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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