BDKRB2

This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq]

Full Name

bradykinin receptor B2

Function

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Biological Process

Arachidonic acid secretion Source: BHF-UCL
Blood circulation Source: ProtInc
Cell surface receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: BHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Source: Ensembl
Negative regulation of peptidyl-serine phosphorylation Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Regulation of vascular permeability Source: BHF-UCL
Regulation of vasoconstriction Source: BHF-UCL
Response to salt stress Source: Ensembl
Smooth muscle contraction Source: BHF-UCL
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
Vasoconstriction Source: InterPro
Vasodilation Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-60 aa
Helical: 61-84 aa
Cytoplasmic: 85-93 aa
Helical: 94-118 aa
Extracellular: 119-131 aa
Helical: 132-153 aa
Cytoplasmic: 154-175 aa
Helical: 176-198 aa
Extracellular: 199-221 aa
Helical: 222-248 aa
Cytoplasmic: 249-267 aa
Helical: 268-292 aa
Extracellular: 293-311 aa
Helical: 312-335 aa
Cytoplasmic: 336-391 aa