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Rabbit Anti-BDKRB2 Recombinant Antibody (CBYY-0465) (CBMAB-0468-YY)

This product is rabbit antibody that recognizes BDKRB2. The antibody CBYY-0465 can be used for immunoassay techniques such as: WB, IP, FC
See all BDKRB2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYY-0465
Antibody Isotype
IgG
Application
WB, IP, FC

Basic Information

Immunogen
Recombinant protein within Human BDKRB2 aa 262-391.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:1,000
IP1:10-1:50
FC1:50-1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
TBS, pH 7.4, 40% glycerol, 0.05% BSA
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 340-390

Target

Full Name
bradykinin receptor B2
Introduction
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforMouse of the protein.
Entrez Gene ID
Human624
Mouse12062
UniProt ID
HumanP30411
MouseP32299
Alternative Names
Bradykinin Receptor B2; BK-2 Receptor; BKR2; B2R; B2 Bradykinin Receptor; BK-2; BRB2; BK2;
Function
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Biological Process
Arachidonic acid secretion Source: BHF-UCL
Blood circulation Source: ProtInc
Cell surface receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: BHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Source: Ensembl
Negative regulation of peptidyl-serine phosphorylation Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Regulation of vascular permeability Source: BHF-UCL
Regulation of vasoconstriction Source: BHF-UCL
Response to salt stress Source: Ensembl
Smooth muscle contraction Source: BHF-UCL
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
Vasoconstriction Source: InterPro
Vasodilation Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-60 aa
Helical: 61-84 aa
Cytoplasmic: 85-93 aa
Helical: 94-118 aa
Extracellular: 119-131 aa
Helical: 132-153 aa
Cytoplasmic: 154-175 aa
Helical: 176-198 aa
Extracellular: 199-221 aa
Helical: 222-248 aa
Cytoplasmic: 249-267 aa
Helical: 268-292 aa
Extracellular: 293-311 aa
Helical: 312-335 aa
Cytoplasmic: 336-391 aa

Ghouse, J., Ahlberg, G., Andreasen, L., Banasik, K., Brunak, S., Schwinn, M., ... & Olesen, M. S. (2021). Association of variants near the bradykinin receptor B2 gene with angioedema in patients taking ACE inhibitors. Journal of the American College of Cardiology, 78(7), 696-709.

Yang, Y., Wang, J., Shi, F., Shan, A., Xu, S., & Lv, W. (2021). BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma. Aging (Albany NY), 13(5), 7499.

Souza, L. V., de Almeida, S. S., De Meneck, F., Thomazini, F., & Araujo, R. C. (2021). Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children. Peptides, 137, 170491.

Ghouse, J., Ahlberg, G., Andreasen, L., Banasik, K., Brunak, S., Schwinn, M., ... & Olesen, M. S. (2020). Common variants near the bradykinin receptor B2 gene are associated with angioedema induced by angiotensin-converting-enzyme inhibitor treatment-a genome wide association study. medRxiv.

Zhou, Y., Wang, W., Wei, R., Jiang, G., Li, F., Chen, X., ... & Xi, L. (2019). Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2. International journal of oncology, 55(1), 131-141.

Zou, H., Wu, G., Lv, J., & Xu, G. (2017). Corrigendum to" Relationship of Angiotensin I-converting Enzyme (ACE) and Bradykinin B2 Receptor (BDKRB2) Polymorphism With Diabetic Nephropathy"[BBA-Molecular Basis of Disease Vol. 1863/Iss. 6 (2017) 1264-1272]. Biochimica et biophysica acta. Molecular basis of disease, 1863(9), 2408.

Zou, H., Wu, G., Lv, J., & Xu, G. (2017). Relationship of angiotensin I-converting enzyme (ACE) and bradykinin B2 receptor (BDKRB2) polymorphism with diabetic nephropathy. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(6), 1264-1272.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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