Rabbit Anti-BDKRB2 Recombinant Antibody (CBYY-1932) (CBMAB-2281-YY)

Name: Rabbit Anti-BDKRB2 Recombinant Antibody (CBYY-1932)
SKU: CBMAB-2281-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBYY-1932

Application

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 302-391 of human BDKRB2.

Host Species

Rabbit

Specificity

Human, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 50% glycerol, 0.05% BSA

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

bradykinin receptor B2

Introduction

This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforMouse of the protein.

Entrez Gene ID

Human	624
Rat	25245

UniProt ID

Human	P30411
Rat	P25023

Alternative Names

Bradykinin Receptor B2; BK-2 Receptor; BKR2; B2R; B2 Bradykinin Receptor; BK-2; BRB2; BK2;

Function

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Biological Process

Arachidonic acid secretion Source: BHF-UCL
Blood circulation Source: ProtInc
Cell surface receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: BHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Source: Ensembl
Negative regulation of peptidyl-serine phosphorylation Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Regulation of vascular permeability Source: BHF-UCL
Regulation of vasoconstriction Source: BHF-UCL
Response to salt stress Source: Ensembl
Smooth muscle contraction Source: BHF-UCL
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
Vasoconstriction Source: InterPro
Vasodilation Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-60 aa
Helical: 61-84 aa
Cytoplasmic: 85-93 aa
Helical: 94-118 aa
Extracellular: 119-131 aa
Helical: 132-153 aa
Cytoplasmic: 154-175 aa
Helical: 176-198 aa
Extracellular: 199-221 aa
Helical: 222-248 aa
Cytoplasmic: 249-267 aa
Helical: 268-292 aa
Extracellular: 293-311 aa
Helical: 312-335 aa
Cytoplasmic: 336-391 aa

Ghouse, J., Ahlberg, G., Andreasen, L., Banasik, K., Brunak, S., Schwinn, M., ... & Olesen, M. S. (2021). Association of variants near the bradykinin receptor B2 gene with angioedema in patients taking ACE inhibitors. Journal of the American College of Cardiology, 78(7), 696-709.

Yang, Y., Wang, J., Shi, F., Shan, A., Xu, S., & Lv, W. (2021). BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma. Aging (Albany NY), 13(5), 7499.

Souza, L. V., de Almeida, S. S., De Meneck, F., Thomazini, F., & Araujo, R. C. (2021). Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children. Peptides, 137, 170491.

Ghouse, J., Ahlberg, G., Andreasen, L., Banasik, K., Brunak, S., Schwinn, M., ... & Olesen, M. S. (2020). Common variants near the bradykinin receptor B2 gene are associated with angioedema induced by angiotensin-converting-enzyme inhibitor treatment-a genome wide association study. medRxiv.

Zhou, Y., Wang, W., Wei, R., Jiang, G., Li, F., Chen, X., ... & Xi, L. (2019). Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2. International journal of oncology, 55(1), 131-141.

Zou, H., Wu, G., Lv, J., & Xu, G. (2017). Corrigendum to" Relationship of Angiotensin I-converting Enzyme (ACE) and Bradykinin B2 Receptor (BDKRB2) Polymorphism With Diabetic Nephropathy"[BBA-Molecular Basis of Disease Vol. 1863/Iss. 6 (2017) 1264-1272]. Biochimica et biophysica acta. Molecular basis of disease, 1863(9), 2408.

Zou, H., Wu, G., Lv, J., & Xu, G. (2017). Relationship of angiotensin I-converting enzyme (ACE) and bradykinin B2 receptor (BDKRB2) polymorphism with diabetic nephropathy. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(6), 1264-1272.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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