CACNG8

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon.

Full Name

Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8

Function

Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity).
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.

Biological Process

Calcium ion transport Source: UniProtKB
Cardiac conduction Source: Reactome
Neurotransmitter receptor internalization Source: GO_Central
Neurotransmitter receptor transport, postsynaptic endosome to lysosome Source: GO_Central
Positive regulation of synaptic transmission, glutamatergic Source: GO_Central
Postsynaptic neurotransmitter receptor diffusion trapping Source: GO_Central
Regulation of AMPA receptor activity Source: UniProtKB
Transmission of nerve impulse Source: GO_Central

Cellular Location

Cell membrane; Postsynaptic density membrane

PTM

Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7.