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Mouse Anti-CACNG8 Recombinant Antibody (CBYJL-240) (CBMAB-L0338-YJ)

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Basic Information

Host Animal
Mouse
Clone
CBYJL-240
Application
WB, IP, IF, E
Immunogen
Amino acids 230-270 mapping within an internal region of L-type Ca++ CP γ8 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8
Introduction
CACNG8 is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. CACNG8 is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon.
Entrez Gene ID
Human59283
Mouse81905
Rat140729
UniProt ID
HumanQ8WXS5
MouseQ8VHW2
RatQ8VHW5
Alternative Names
Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8; Neuronal Voltage-Gated Calcium Channel Gamma-8 Subunit; Calcium Channel; Voltage-Dependent; Gamma Subunit 8; Transmembrane AMPAR Regulatory Protein Gamma-8; TARP Gamma-8; CACNG6
Function
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity).
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.
Biological Process
Calcium ion transport Source: UniProtKB
Cardiac conduction Source: Reactome
Neurotransmitter receptor internalization Source: GO_Central
Neurotransmitter receptor transport, postsynaptic endosome to lysosome Source: GO_Central
Positive regulation of synaptic transmission, glutamatergic Source: GO_Central
Postsynaptic neurotransmitter receptor diffusion trapping Source: GO_Central
Regulation of AMPA receptor activity Source: UniProtKB
Transmission of nerve impulse Source: GO_Central
Cellular Location
Cell membrane; Postsynaptic density membrane
PTM
Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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