CAPZA3

CAPZA3 (Capping Actin Protein Of Muscle Z-Line Alpha Subunit 3) is a Protein Coding gene. Among its related pathways are Endocytosis and Cell cycle_Spindle assembly and chromosome separation. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is CAPZA1.

Full Name

Capping Actin Protein Of Muscle Z-Line Alpha Subunit 3

Function

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).

Biological Process

Actin cytoskeleton organization Source: GO_Central
Actin filament organization Source: Ensembl
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Barbed-end actin filament capping Source: GO_Central
Cytoplasm organization Source: Ensembl
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Spermatid development Source: Ensembl

Cellular Location

Cortical cytoskeleton; F-actin capping protein complex; Cytosol; Nucleus; Membrane; Sperm head