Mouse Anti-CAPZA3 Recombinant Antibody (CBL-LY-002) (CBMAB-C9401-LY)

Name: Mouse Anti-CAPZA3 Recombinant Antibody (CBL-LY-002)
SKU: CBMAB-C9401-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBL-LY-002

Application

ELISA, WB

Immunogen

Recombinant protein corresponding to full length CapZ alpha-2.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Capping Actin Protein Of Muscle Z-Line Alpha Subunit 3

Introduction

CAPZA1 (Capping Actin Protein Of Muscle Z-Line Alpha Subunit 1) is a Protein Coding gene. Diseases associated with CAPZA1 include Autosomal Recessive Primary Microcephaly. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include actin binding.
An important paralog of this gene is CAPZA2.

Entrez Gene ID

93661

UniProt ID

Q96KX2

Alternative Names

Capping Actin Protein Of Muscle Z-Line Alpha Subunit 3; Capping Protein (Actin Filament) Muscle Z-Line, Alpha 3; Germ Cell-Specific Protein 3; CapZ Alpha-3; CP-Alpha-3; Gsg3; Testis Tissue Sperm-Binding Protein Li 73n;

Function

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).

Biological Process

Actin cytoskeleton organization Source: GO_Central
Actin filament organization Source: Ensembl
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Barbed-end actin filament capping Source: GO_Central
Cytoplasm organization Source: Ensembl
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Spermatid development Source: Ensembl

Cellular Location

Cortical cytoskeleton; F-actin capping protein complex; Cytosol; Nucleus; Membrane; Sperm head

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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