CASPR1

The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.

Full Name

contactin associated protein 1

Function

Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.

Biological Process

Cell adhesion Source: UniProtKB-KW
Central nervous system myelination Source: UniProtKB
Cytoskeleton organization Source: BHF-UCL
Myelination Source: BHF-UCL
Myelination in peripheral nervous system Source: UniProtKB
Neuromuscular process controlling balance Source: BHF-UCL
Neuromuscular process controlling posture Source: BHF-UCL
Neuronal action potential propagation Source: BHF-UCL
Neuron projection development Source: RGD
Neuron projection morphogenesis Source: BHF-UCL
Paranodal junction assembly Source: BHF-UCL
Protein localization to juxtaparanode region of axon Source: UniProtKB
Protein localization to paranode region of axon Source: BHF-UCL

Cellular Location

Membrane; Paranodal septate junction

Topology

Extracellular: 21-1284
Helical: 1285-1305
Cytoplasmic: 1306-1381