CAT

CAT (Catalase) is a Protein Coding gene. Diseases associated with CAT include Acatalasemia and Pityriasis Versicolor. Among its related pathways are DNA Damage Response (only ATM dependent) and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding.

Catalase

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.

Aerobic respiration Source: Ensembl
Aging Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Cellular response to oxidative stress Source: Reactome
Cholesterol metabolic process Source: Ensembl
Hemoglobin metabolic process Source: Ensembl
Hydrogen peroxide catabolic process Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of NF-kappaB transcription factor activity Source: Ensembl
Neutrophil degranulation Source: Reactome
Osteoblast differentiation Source: UniProtKB
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of NF-kappaB transcription factor activity Source: Ensembl
Positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
Protein localization Source: Reactome
Response to activity Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to drug Source: Ensembl
Response to estradiol Source: Ensembl
Response to ethanol Source: Ensembl
Response to fatty acid Source: Ensembl
Response to hydrogen peroxide Source: GO_Central
Response to hyperoxia Source: Ensembl
Response to hypoxia Source: Ensembl
Response to inactivity Source: Ensembl
Response to insulin Source: Ensembl
Response to L-ascorbic acid Source: Ensembl
Response to lead ion Source: Ensembl
Response to light intensity Source: Ensembl
Response to ozone Source: Ensembl
Response to phenylpropanoid Source: Ensembl
Response to reactive oxygen species Source: UniProtKB
Response to vitamin A Source: Ensembl
Response to vitamin E Source: Ensembl
Triglyceride metabolic process Source: Ensembl
Ureteric bud development Source: Ensembl
UV protection Source: UniProtKB

Peroxisome

Acatalasemia (ACATLAS): A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Acatalasemia is inherited as an autosomal recessive trait.

The N-terminus is blocked.