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Mouse Anti-CAT Recombinant Antibody (CBFYC-0869) (CBMAB-C0924-FY)

This product is mouse antibody that recognizes CAT. The antibody CBFYC-0869 can be used for immunoassay techniques such as: WB.
See all CAT antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human, Rat
Clone
CBFYC-0869
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Recombinant human protein purified from E. coli
Specificity
Mouse, Human, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Catalase
Introduction
CAT (Catalase) is a Protein Coding gene. Diseases associated with CAT include Acatalasemia and Pityriasis Versicolor. Among its related pathways are DNA Damage Response (only ATM dependent) and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding.
Entrez Gene ID
Human847
Mouse12359
Rat24248
UniProt ID
HumanP04040
MouseP24270
RatP04762
Alternative Names
Catalase; EC 1.11.1.
Function
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
Biological Process
Aerobic respiration Source: Ensembl
Aging Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Cellular response to oxidative stress Source: Reactome
Cholesterol metabolic process Source: Ensembl
Hemoglobin metabolic process Source: Ensembl
Hydrogen peroxide catabolic process Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of NF-kappaB transcription factor activity Source: Ensembl
Neutrophil degranulation Source: Reactome
Osteoblast differentiation Source: UniProtKB
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of NF-kappaB transcription factor activity Source: Ensembl
Positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
Protein localization Source: Reactome
Response to activity Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to drug Source: Ensembl
Response to estradiol Source: Ensembl
Response to ethanol Source: Ensembl
Response to fatty acid Source: Ensembl
Response to hydrogen peroxide Source: GO_Central
Response to hyperoxia Source: Ensembl
Response to hypoxia Source: Ensembl
Response to inactivity Source: Ensembl
Response to insulin Source: Ensembl
Response to L-ascorbic acid Source: Ensembl
Response to lead ion Source: Ensembl
Response to light intensity Source: Ensembl
Response to ozone Source: Ensembl
Response to phenylpropanoid Source: Ensembl
Response to reactive oxygen species Source: UniProtKB
Response to vitamin A Source: Ensembl
Response to vitamin E Source: Ensembl
Triglyceride metabolic process Source: Ensembl
Ureteric bud development Source: Ensembl
UV protection Source: UniProtKB
Cellular Location
Peroxisome
Involvement in disease
Acatalasemia (ACATLAS): A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Acatalasemia is inherited as an autosomal recessive trait.
PTM
The N-terminus is blocked.

Shi, C., Li, M., Zhang, Z., Yao, Q., Shao, K., Xu, F., ... & Peng, X. (2020). Catalase-based liposomal for reversing immunosuppressive tumor microenvironment and enhanced cancer chemo-photodynamic therapy. Biomaterials, 233, 119755.

Jing, M., Han, G., Wan, J., Zhang, S., Yang, J., Zong, W., ... & Liu, R. (2020). Catalase and superoxide dismutase response and the underlying molecular mechanism for naphthalene. Science of The Total Environment, 736, 139567.

Li, G., Yuan, S., Deng, D., Ou, T., Li, Y., Sun, R., ... & Wu, S. (2019). Fluorinated polyethylenimine to enable transmucosal delivery of photosensitizer‐conjugated catalase for photodynamic therapy of orthotopic bladder tumors postintravesical instillation. Advanced Functional Materials, 29(40), 1901932.

Phua, S. Z. F., Yang, G., Lim, W. Q., Verma, A., Chen, H., Thanabalu, T., & Zhao, Y. (2019). Catalase-integrated hyaluronic acid as nanocarriers for enhanced photodynamic therapy in solid tumor. ACS nano, 13(4), 4742-4751.

Wang, W., Cheng, Y., Chen, D., Liu, D., Hu, M., Dong, J., ... & Shen, F. (2019). The catalase gene family in cotton: genome-wide characterization and bioinformatics analysis. Cells, 8(2), 86.

Tuzet, A., Rahantaniaina, M. S., & Noctor, G. (2019). Analyzing the function of catalase and the ascorbate–glutathione pathway in H2O2 processing: insights from an experimentally constrained kinetic model. Antioxidants & redox signaling, 30(9), 1238-1268.

Zhang, M., Yang, N., Liu, Y., & Tang, J. (2019). Synthesis of catalase-inorganic hybrid nanoflowers via sonication for colorimetric detection of hydrogen peroxide. Enzyme and microbial technology, 128, 22-25.

Xu, M., Cui, Z., Zhao, L., Hu, S., Zong, W., & Liu, R. (2018). Characterizing the binding interactions of PFOA and PFOS with catalase at the molecular level. Chemosphere, 203, 360-367.

Ighodaro, O. M., & Akinloye, O. A. (2018). First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria journal of medicine, 54(4), 287-293.

Chen, L., Zhang, J., Zhu, Y., & Zhang, Y. (2018). Interaction of chromium (III) or chromium (VI) with catalase and its effect on the structure and function of catalase: an in vitro study. Food chemistry, 244, 378-385.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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