CCL12

Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CCchemokine family that has been described in mice. It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine. CCL12 specifically attractseosinophils, monocytes and lymphocytes.

Full Name

chemokine (C-C motif) ligand 12

Function

Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.

Biological Process

Angiogenesis Source: BHF-UCL
Astrocyte cell migration Source: MGI
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to organic cyclic compound Source: MGI
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Cytokine-mediated signaling pathway Source: MGI
Cytoskeleton organization Source: MGI
Eosinophil chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: BHF-UCL
Lipopolysaccharide-mediated signaling pathway Source: MGI
Lymphocyte chemotaxis Source: GO_Central
Macrophage chemotaxis Source: MGI
MAPK cascade Source: MGI
Monocyte chemotaxis Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle Source: MGI
Negative regulation of glial cell apoptotic process Source: MGI
Negative regulation of leukocyte proliferation Source: MGI
Negative regulation of natural killer cell chemotaxis Source: MGI
Negative regulation of neuron apoptotic process Source: MGI
Negative regulation of vascular endothelial cell proliferation Source: MGI
Neutrophil chemotaxis Source: GO_Central
Positive regulation of calcium ion import Source: MGI
Positive regulation of endothelial cell apoptotic process Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of leukocyte migration Source: MGI
Protein kinase B signaling Source: MGI
Regulation of cell shape Source: MGI

Cellular Location

Secreted