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Rat Anti-CCL12 Recombinant Antibody (8J25) (CBMAB-C9269-LY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
8J25
Antibody Isotype
IgG2
Application
Neutralization, WB

Basic Information

Immunogen
Mouse recombinant protein of CCL-12/MCP-5.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
chemokine (C-C motif) ligand 12
Entrez Gene ID
20293
UniProt ID
Q62401
Function
Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
Biological Process
Angiogenesis Source: BHF-UCL
Astrocyte cell migration Source: MGI
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to organic cyclic compound Source: MGI
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Cytokine-mediated signaling pathway Source: MGI
Cytoskeleton organization Source: MGI
Eosinophil chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: BHF-UCL
Lipopolysaccharide-mediated signaling pathway Source: MGI
Lymphocyte chemotaxis Source: GO_Central
Macrophage chemotaxis Source: MGI
MAPK cascade Source: MGI
Monocyte chemotaxis Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle Source: MGI
Negative regulation of glial cell apoptotic process Source: MGI
Negative regulation of leukocyte proliferation Source: MGI
Negative regulation of natural killer cell chemotaxis Source: MGI
Negative regulation of neuron apoptotic process Source: MGI
Negative regulation of vascular endothelial cell proliferation Source: MGI
Neutrophil chemotaxis Source: GO_Central
Positive regulation of calcium ion import Source: MGI
Positive regulation of endothelial cell apoptotic process Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of leukocyte migration Source: MGI
Protein kinase B signaling Source: MGI
Regulation of cell shape Source: MGI
Cellular Location
Secreted
More Infomation

Chen, J., & Lai, X. (2021). C–X–C motif chemokine ligand 12: a potential therapeutic target in Duchenne muscular dystrophy. Bioengineered, 12(1), 5428-5439.

Qin, C., Memon, N. H., Gong, Q., Shi, Q., & Yang, Q. (2021). Diurnal expression of CXC receptors 4 (CXCR4) and CXC chemokine ligand 12 (CXCL12) in Pelteobagrus vachellii. Chronobiology International, 1-9.

Mochizuki, K., Oishi, N., Kawai, M., Odate, T., Tahara, I., Inoue, T., ... & Kondo, T. (2021). Expressions of CXCL12, CXCL10 and CCL18 in Warthin tumors characterized pathologically. Cell. Mol. Immunol, 15, 299-311.

Shi, Y., Riese, D. J., & Shen, J. (2020). The role of the CXCL12/CXCR4/CXCR7 chemokine axis in cancer. Frontiers in Pharmacology, 11, 1969.

Andrés-Benito, P., Povedano, M., Domínguez, R., Marco, C., Colomina, M. J., López-Pérez, Ó., ... & Ferrer, I. (2020). Increased CXC motif chemokine ligand 12 levels in cerebrospinal fluid as a candidate biomarker in sporadic amyotrophic lateral sclerosis. International Journal of Molecular Sciences, 21(22), 8680.

Li, F., Xu, X., Geng, J., Wan, X., & Dai, H. (2020). The autocrine CXCR4/CXCL12 axis contributes to lung fibrosis through modulation of lung fibroblast activity. Experimental and therapeutic medicine, 19(3), 1844-1854.

Bu, Y., & Zhao, D. (2020). Luteolin retards CXCL12-induced Jurkat cells migration by disrupting transcription of CXCR4. Experimental and molecular pathology, 113, 104370.

Zhang, B., Wu, C., Zhang, Z., Yan, K., Li, C., Li, Y., & Li, L. (2019). CXCL12 is associated with FoxP3+ tumor‑infiltrating lymphocytes and affects the survival of patients with oral squamous cell carcinoma. Oncology letters, 18(2), 1099-1106.

Han, J., Jeong, W., Gu, M. J., Yoo, I., Yun, C. H., Kim, J., & Ka, H. (2018). Cysteine-X-cysteine motif chemokine ligand 12 and its receptor CXCR4: expression, regulation, and possible function at the maternal–conceptus interface during early pregnancy in pigs. Biology of reproduction, 99(6), 1137-1148.

Meng, W., Xue, S., & Chen, Y. (2018). The role of CXCL12 in tumor microenvironment. Gene, 641, 105-110.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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