CCL19

CCL19 (C-C Motif Chemokine Ligand 19) is a Protein Coding gene. Diseases associated with CCL19 include Lymphoproliferative Syndrome 2 and Leukemia, Chronic Lymphocytic. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include chemokine activity and CCR10 chemokine receptor binding.

C-C Motif Chemokine Ligand 19

May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Activation of JUN kinase activity Source: BHF-UCL
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell communication Source: ProtInc
Cell maturation Source: BHF-UCL
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Cellular response to virus Source: UniProtKB
Chemokine-mediated signaling pathway Source: GO_Central
Cytokine-mediated signaling pathway Source: Reactome
Dendritic cell chemotaxis Source: BHF-UCL
Establishment of T cell polarity Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Immunological synapse formation Source: BHF-UCL
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Mature conventional dendritic cell differentiation Source: BHF-UCL
Monocyte chemotaxis Source: GO_Central
Myeloid dendritic cell chemotaxis Source: BHF-UCL
Negative regulation of dendritic cell apoptotic process Source: BHF-UCL
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell motility Source: BHF-UCL
Positive regulation of chemotaxis Source: BHF-UCL
Positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
Positive regulation of dendritic cell dendrite assembly Source: BHF-UCL
Positive regulation of endocytosis Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of glycoprotein biosynthetic process Source: BHF-UCL
Positive regulation of GTPase activity Source: BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
Positive regulation of interleukin-12 production Source: BHF-UCL
Positive regulation of interleukin-1 beta production Source: BHF-UCL
Positive regulation of JNK cascade Source: BHF-UCL
Positive regulation of neutrophil chemotaxis Source: BHF-UCL
Positive regulation of NIK/NF-kappaB signaling Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of receptor-mediated endocytosis Source: BHF-UCL
Positive regulation of T cell proliferation Source: BHF-UCL
Positive regulation of T-helper 1 cell differentiation Source: BHF-UCL
Positive regulation of tumor necrosis factor production Source: BHF-UCL
Regulation of cell projection assembly Source: BHF-UCL
Release of sequestered calcium ion into cytosol Source: BHF-UCL
Response to nitric oxide Source: BHF-UCL
Response to prostaglandin E Source: BHF-UCL
Response to virus Source: ProtInc
T cell costimulation Source: BHF-UCL

Secreted