CCNA2

CCNA2 (Cyclin A2) is a Protein Coding gene. Diseases associated with CCNA2 include Splenic Diffuse Red Pulp Small B-Cell Lymphoma and Valproate Embryopathy. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Signaling events mediated by PRL. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA1.

Full Name

Cyclin A2

Function

Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.

Biological Process

Animal organ regeneration Source: Ensembl
Cell cycle G1/S phase transition Source: UniProtKB
Cell division Source: UniProtKB-KW
Cellular response to cocaine Source: Ensembl
Cellular response to estradiol stimulus Source: Ensembl
Cellular response to hypoxia Source: Ensembl
Cellular response to insulin-like growth factor stimulus Source: Ensembl
Cellular response to leptin stimulus Source: Ensembl
Cellular response to luteinizing hormone stimulus Source: Ensembl
Cellular response to nitric oxide Source: Ensembl
Cellular response to platelet-derived growth factor stimulus Source: Ensembl
Cochlea development Source: Ensembl
G2/M transition of mitotic cell cycle Source: UniProtKB
Histone phosphorylation Source: CAFA
Mitotic cell cycle phase transition Source: GO_Central
Positive regulation of fibroblast proliferation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: Ensembl
Protein deubiquitination Source: Reactome
Ras protein signal transduction Source: BHF-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of DNA replication Source: UniProtKB
Response to glucagon Source: Ensembl
Viral process Source: UniProtKB-KW

Cellular Location

Cytoplasm; Nucleus. Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606).

PTM

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.