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Mouse Anti-CCNA2 (N-terminus) Recombinant Antibody (CBYY-C3098) (CBMAB-C4541-YY)

This product is mouse antibody that recognizes CCNA2. The antibody CBYY-C3098 can be used for immunoassay techniques such as: IHC, IP, WB
See all CCNA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C3098
Antibody Isotype
IgG1, κ
Application
IHC, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Tissue culture supernatant
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
Cyclin A2
Entrez Gene ID
890
UniProt ID
P20248
Alternative Names
CD8a Molecule; T-Lymphocyte Differentiation Antigen T8/Leu-2; T-Cell Surface Glycoprotein CD8 Alpha Chain; CD8 Antigen, Alpha Polypeptide (P32); MAL; Leu2 T-Lymphocyte Antigen; OKT8 T-Cell Antigen; T-Cell Antigen Leu2;
Function
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
Biological Process
Animal organ regeneration Source: Ensembl
Cell cycle G1/S phase transition Source: UniProtKB
Cell division Source: UniProtKB-KW
Cellular response to cocaine Source: Ensembl
Cellular response to estradiol stimulus Source: Ensembl
Cellular response to hypoxia Source: Ensembl
Cellular response to insulin-like growth factor stimulus Source: Ensembl
Cellular response to leptin stimulus Source: Ensembl
Cellular response to luteinizing hormone stimulus Source: Ensembl
Cellular response to nitric oxide Source: Ensembl
Cellular response to platelet-derived growth factor stimulus Source: Ensembl
Cochlea development Source: Ensembl
G2/M transition of mitotic cell cycle Source: UniProtKB
Histone phosphorylation Source: CAFA
Mitotic cell cycle phase transition Source: GO_Central
Positive regulation of fibroblast proliferation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: Ensembl
Protein deubiquitination Source: Reactome
Ras protein signal transduction Source: BHF-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of DNA replication Source: UniProtKB
Response to glucagon Source: Ensembl
Viral process Source: UniProtKB-KW
Cellular Location
Cytoplasm; Nucleus. Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606).
PTM
Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.

Lu, Y., Su, F., Yang, H., Xiao, Y., Zhang, X., Su, H., ... & Ling, X. (2021). E2F1 transcriptionally regulates CCNA2 expression to promote triple negative breast cancer tumorigenicity. Cancer Biomarkers, (Preprint), 1-14.

Wang, H., Fu, L., Wei, D., Wang, B., Zhang, C., Zhu, T., ... & Yu, G. (2020). MiR-29c-3p suppresses the migration, invasion and cell cycle in esophageal carcinoma via CCNA2/p53 axis. Frontiers in bioengineering and biotechnology, 8, 75.

Lee, Y., Lee, C. E., Oh, S., Kim, H., Lee, J., Kim, S. B., & Kim, H. S. (2020). Pharmacogenomic analysis reveals CCNA2 as a predictive biomarker of sensitivity to polo-like kinase I inhibitor in gastric cancer. Cancers, 12(6), 1418.

Yang, R., Du, Y., Wang, L., Chen, Z., & Liu, X. (2020). Weighted gene co-expression network analysis identifies CCNA2 as a treatment target of prostate cancer through inhibiting cell cycle. Journal of Cancer, 11(5), 1203.

Yang, L., Zeng, W., Sun, H., Huang, F., Yang, C., Cai, X., ... & Yang, K. (2020). Bioinformatical analysis of gene expression omnibus database associates TAF7/CCNB1, TAF7/CCNA2, and GTF2E2/CDC20 pathways with glioblastoma development and prognosis. World neurosurgery, 138, e492-e514.

Li, X., Ma, X. L., Tian, F. J., Wu, F., Zhang, J., Zeng, W. H., ... & Zhang, Y. (2019). Downregulation of CCNA2 disturbs trophoblast migration, proliferation, and apoptosis during the pathogenesis of recurrent miscarriage. American Journal of Reproductive Immunology, 82(1), e13144.

Shekhar, R., Priyanka, P., Kumar, P., Ghosh, T., Khan, M. M., Nagarajan, P., & Saxena, S. (2019). The microRNAs miR-449a and miR-424 suppress osteosarcoma by targeting cyclin A2 expression. Journal of Biological Chemistry, 294(12), 4381-4400.

Alves, M. J., Goksel, M., Kaya, B., Mostafa, H., Gygli, P., Stephens, J., ... & Czeisler, C. M. (2019). CCNA2 Ablation in Aged Mice Results in Abnormal rRNA Granule Accumulation in Hippocampus. The American journal of pathology, 189(2), 426-439.

Bayard, Q., Meunier, L., Peneau, C., Renault, V., Shinde, J., Nault, J. C., ... & Letouzé, E. (2018). Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress. Nature communications, 9(1), 1-14.

Ruan, J. S., Zhou, H., Yang, L., Wang, L., Jiang, Z. S., & Wang, S. M. (2017). CCNA2 facilitates epithelial-to-mesenchymal transition via the integrin αvβ3 signaling in NSCLC. International journal of clinical and experimental pathology, 10(8), 8324.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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