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CCND3

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.

Full Name

Cyclin D3

Function

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Biological Process

Cell division Source: UniProtKB-KW
Mitotic cell cycle phase transition Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Positive regulation of G1/S transition of mitotic cell cycle Source: GO_Central
Positive regulation of protein phosphorylation Source: BHF-UCL
Regulation of cell population proliferation Source: Ensembl
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of insulin receptor signaling pathway Source: Ensembl
Signal transduction Source: Ensembl
T cell proliferation Source: Ensembl

Cellular Location

Cytoplasm; Nucleus; Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.

PTM

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.

Anti-CCND3 antibodies

Mouse Anti-CCND3 Recombinant Antibody (CBXC-1600) (CBMAB-C4842-CQ)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBXC-1600

Application*: IH, WB

Mouse Anti-CCND3 Recombinant Antibody (CBXC-2681) (CBMAB-C4841-CQ)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-2681

Application*: E, WB, IH

Mouse Anti-CCND3 Recombinant Antibody (CBXC-0147) (CBMAB-C4840-CQ)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0147

Application*: IP, WB

Mouse Anti-CCND3 Recombinant Antibody (CBXC-0146) (CBMAB-C4839-CQ)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXC-0146

Application*: F, IF, IH, IP, N, WB

Mouse Anti-CCND3 Recombinant Antibody (CBXC-1375) (CBMAB-C2599-CQ)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBXC-1375

Application*: IP, WB

Mouse Anti-CCND3 Recombinant Antibody (DCS-22) (CBMAB-C0621-CQ)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: DCS-22

Application*: WB, P, C

Mouse Anti-CCND3 Recombinant Antibody (CBFYC-1042) (CBMAB-C1099-FY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBFYC-1042

Application*: F, IF, IH, IP, N, WB

Mouse Anti-CCND3 Recombinant Antibody (CBFYC-1041) (CBMAB-C1098-FY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-1041

Application*: DB

Mouse Anti-CCND3 (AA 127-292) Recombinant Antibody (CBFYC-1040) (CBMAB-C1097-FY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse, Dog, Human, Rat

Clone: CBFYC-1040

Application*: WB, IF, IH, IP

Mouse Anti-CCND3 Recombinant Antibody (CBFYC-1039) (CBMAB-C1096-FY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1039

Application*: siRNA, E, IH, WB

Mouse Anti-CCND3 Recombinant Antibody (CBFYC-1038) (CBMAB-C1095-FY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1038

Application*: IC, IH, IP, WB

Mouse Anti-CCND3 Recombinant Antibody (6H4) (CBMAB-C8352-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: 6H4

Application*: E, WB

Mouse Anti-CCND3 Recombinant Antibody (DCS2.2) (CBMAB-AP906LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: DCS2.2

Application*: IHC, IP, WB

Mouse Anti-CCND3 Recombinant Antibody (CBMAB-AO158LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Application*: ELISA, WB, IHC

Recombinant Rabbit Anti-CCND3 Antibody (CBAb053) (CBMAB-Ab053-LY)

SDS

Target: CCND3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBAb053

Application*: WB

Mouse Anti-CCND3 Recombinant Antibody (TS106) (CBMAB-C9909-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: TS106

Application*: IH, WB

Mouse Anti-CCND3 Recombinant Antibody (SPM241) (CBMAB-C9908-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: SPM241

Application*: P

Rabbit Anti-CCND3 Recombinant Antibody (SP207) (CBMAB-C9906-LY)

SDS

Target: CCND3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Cattle, Human, Mouse, Rat

Clone: SP207

Application*: WB, F

Mouse Anti-CCND3 Recombinant Antibody (DCS-2.2) (CBMAB-C1459-CN)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey, Mouse, Rat

Clone: DCS-2.2

Application*: IH, IP, WB

Mouse Anti-CCND3 Recombinant Antibody (CY-D3) (CBMAB-C1458-CN)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CY-D3

Application*: IF, WB

Mouse Anti-CCND3 Recombinant Antibody (CBYY-C0337) (CBMAB-C1127-YY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C0337

Application*: WB, IH

Mouse Anti-CCND3 Recombinant Antibody (8J105) (CBMAB-C9241-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 8J105

Application*: DB, WB

Mouse Anti-CCND3 Recombinant Antibody (5F181) (CBMAB-C7553-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5F181

Application*: F, C, WB

Mouse Anti-CCND3 Recombinant Antibody (588726) (CBMAB-C7236-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 588726

Application*: WB, IH

Mouse Anti-CCND3 Recombinant Antibody (3i12) (CBMAB-C6381-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3i12

Application*: C, WB

Mouse Anti-CCND3 Recombinant Antibody (1F2C6) (CBMAB-C4039-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1F2C6

Application*: E, C, WB

Mouse Anti-CCND3 Recombinant Antibody (13B106) (CBMAB-C2765-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 13B106

Application*: E, WB

Mouse Anti-CCND3 Recombinant Antibody (10K179) (CBMAB-C2397-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 10K179

Application*: IC, IH, IP, WB

Mouse Anti-CCND3 Recombinant Antibody (1) (CBMAB-C1988-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Dog, Rat

Clone: 1

Application*: WB, IF, IH, IP

Mouse Anti-CCND3 Recombinant Antibody (0.N.243) (CBMAB-C1416-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat

Clone: 0.N.243

Application*: IP, WB

Mouse Anti-CCND3 Recombinant Antibody (0.N.242) (CBMAB-C1415-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Monkey, Mouse, Rat

Clone: 0.N.242

Application*: F, IF, IH, IP, N, WB

Mouse Anti-CCND3 Recombinant Antibody (2120C1a) (CBMAB-C0605-LY)

SDS

Target: CCND3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2120C1a

Application*: DB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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