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Mouse Anti-CCND3 Recombinant Antibody (CBYY-C0337) (CBMAB-C1127-YY)

This product is mouse antibody that recognizes CCND3. The antibody CBYY-C0337 can be used for immunoassay techniques such as: WB, IHC
See all CCND3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C0337
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
E.coli-derived recombinant human Cyclin D3, Met1-Leu292, Accession # P30281
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A/G purified
Buffer
LYOPH
Preservative
PBS
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclin D3
Entrez Gene ID
896
UniProt ID
P30281
Alternative Names
Bone Marrow Stromal Cell Antigen 1; ADP-Ribosyl Cyclase 2; Bone Marrow Stromal Antigen 1; Cyclic ADP-Ribose Hydrolase 2; NAD(+) Nucleosidase; CADPr Hydrolase 2;
Function
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Biological Process
Cell division Source: UniProtKB-KW
Mitotic cell cycle phase transition Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Positive regulation of G1/S transition of mitotic cell cycle Source: GO_Central
Positive regulation of protein phosphorylation Source: BHF-UCL
Regulation of cell population proliferation Source: Ensembl
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of insulin receptor signaling pathway Source: Ensembl
Signal transduction Source: Ensembl
T cell proliferation Source: Ensembl
Cellular Location
Cytoplasm; Nucleus; Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.
PTM
Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.

Smith, C. C., Viny, A. D., Massi, E., Kandoth, C., Socci, N. D., Rapaport, F., ... & Shah, N. P. (2021). Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia. Clinical Cancer Research.

Pae, J., Ersching, J., Castro, T. B., Schips, M., Mesin, L., Allon, S. J., ... & Victora, G. D. (2021). Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells. Journal of Experimental Medicine, 218(4).

Wu, H., Wang, C., Liu, Y., Yang, C., Liang, X., Zhang, X., & Li, X. (2020). miR‑138‑5p suppresses glioblastoma cell viability and leads to cell cycle arrest by targeting cyclin D3. Oncology Letters, 20(5), 1-1.

Ramezani-Rad, P., Chen, C., Zhu, Z., & Rickert, R. C. (2020). Cyclin D3 governs clonal expansion of dark zone germinal center B cells. Cell reports, 33(7), 108403.

Martín-Garcia, D., Navarro, A., Valdés-Mas, R., Clot, G., Gutiérrez-Abril, J., Prieto, M., ... & Beà, S. (2019). CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1− mantle cell lymphoma. Blood, The Journal of the American Society of Hematology, 133(9), 940-951.

Kang, H., Heo, S., Shin, J. J., Ji, E., Tak, H., Ahn, S., ... & Kim, W. (2019). A miR‐194/PTBP1/CCND3 axis regulates tumor growth in human hepatocellular carcinoma. The Journal of pathology, 249(3), 395-408.

Ding, Z. Y., Li, R., Zhang, Q. J., Wang, Y., Jiang, Y., Meng, Q. Y., ... & Wu, G. H. (2019). Prognostic role of cyclin D2/D3 in multiple human malignant neoplasms: A systematic review and meta‐analysis. Cancer medicine, 8(6), 2717-2729.

Demin, D. E., Bogolyubova, A. V., Zlenko, D. V., Uvarova, A. N., Deikin, A. V., Putlyaeva, L. V., ... & Schwartz, A. M. (2018). The novel short isoform of securin stimulates the expression of cyclin D3 and angiogenesis factors VEGFA and FGF2, but does not affect the expression of MYC transcription factor. Molecular Biology, 52(3), 436-445.

Yu, X., Zhang, Y., Cavazos, D., Ma, X., Zhao, Z., Du, L., & Pertsemlidis, A. (2018). miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer. Cell death & disease, 9(2), 1-12.

Curiel-Olmo, S., Mondéjar, R., Almaraz, C., Mollejo, M., Cereceda, L., Marès, R., ... & Martínez, N. (2017). Splenic diffuse red pulp small B-cell lymphoma displays increased expression of cyclin D3 and recurrent CCND3 mutations. Blood, The Journal of the American Society of Hematology, 129(8), 1042-1045.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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