CDAN1

CDAN1 (Codanin 1) is a Protein Coding gene. Diseases associated with CDAN1 include Anemia, Congenital Dyserythropoietic, Type Ia and Congenital Dyserythropoietic Anemia.

Full Name

Codanin 1

Function

May act as a negative regulator of ASF1 in chromatin assembly.

Biological Process

Chromatin assembly Source: UniProtKB
Chromatin organization Source: MGI
Negative regulation of DNA replication Source: UniProtKB
Protein localization Source: MGI

Cellular Location

Nucleus; Cytoplasm; Membrane. Mainly detected as a cytoplasmic protein.

Involvement in disease

Anemia, congenital dyserythropoietic, 1A (CDAN1A): An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts.