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Mouse Anti-CDAN1 Recombinant Antibody (Cod177) (CBMAB-C0597-CQ)

This product is a mouse antibody that recognizes CDAN1. The antibody Cod177 can be used for immunoassay techniques such as: WB, IF.
See all CDAN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
Cod177
Antibody Isotype
IgG2b
Application
WB, IF

Basic Information

Immunogen
AA 294-607 of cloned human protein
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Codanin 1
Introduction
CDAN1 (Codanin 1) is a Protein Coding gene. Diseases associated with CDAN1 include Anemia, Congenital Dyserythropoietic, Type Ia and Congenital Dyserythropoietic Anemia.
Entrez Gene ID
Human146059
Mouse68968
UniProt ID
HumanQ8IWY9
MouseQ8CC12
Alternative Names
Codanin 1; Congenital Dyserythropoietic Anemia, Type I; Discs Lost Homolog; Codanin-1; PRO1295; CDAN1A; CDA1; CDAI; DLT;
Function
May act as a negative regulator of ASF1 in chromatin assembly.
Biological Process
Chromatin assembly Source: UniProtKB
Chromatin organization Source: MGI
Negative regulation of DNA replication Source: UniProtKB
Protein localization Source: MGI
Cellular Location
Nucleus; Cytoplasm; Membrane. Mainly detected as a cytoplasmic protein.
Involvement in disease
Anemia, congenital dyserythropoietic, 1A (CDAN1A): An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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