CLCN6

This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]

Full Name

Chloride Voltage-Gated Channel 6

Function

Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.

Biological Process

Cell volume homeostasis Source: UniProtKB
Chloride transport Source: UniProtKB
Ion transmembrane transport Source: Reactome
Response to mechanical stimulus Source: Ensembl
Signal transduction Source: UniProtKB

Cellular Location

Endosome membrane. Detected in detergent-resistant lipid rafts.

Topology

Cytoplasmic: 1-80
Helical: 81-113
Helical: 128-150
Helical: 159-166
Helical: 176-194
Helical: 200-217
Helical: 241-253
Helical: 257-265
Helical: 277-294
Helical: 335-364
Helical: 371-392
Helical: 462-481
Helical: 487-511
Helical: 519-533
Loop between two helices: 534-536
Helical: 537-548
Loop between two helices: 549-552
Helical: 553-571
Cytoplasmic: 572-869

PTM

N-glycosylated on several asparagine residues.