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Mouse Anti-CLCN6 Recombinant Antibody (2H2) (CBMAB-C5252-LY)

This product is antibody recognizes CLCN6. The antibody 2H2 immunoassay techniques such as: ELISA, IF, WB.
See all CLCN6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2H2
Antibody Isotype
IgG2b, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chloride Voltage-Gated Channel 6
Introduction
This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]
Entrez Gene ID
1185
UniProt ID
P51797
Alternative Names
Chloride Voltage-Gated Channel 6; Chloride Channel, Voltage-Sensitive 6; CLC-6; Chloride Transport Protein 6; Chloride Channel Protein 6; Chloride Channel 6; KIAA0046;
Function
Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.
Biological Process
Cell volume homeostasis Source: UniProtKB
Chloride transport Source: UniProtKB
Ion transmembrane transport Source: Reactome
Response to mechanical stimulus Source: Ensembl
Signal transduction Source: UniProtKB
Cellular Location
Endosome membrane. Detected in detergent-resistant lipid rafts.
Topology
Cytoplasmic: 1-80
Helical: 81-113
Helical: 128-150
Helical: 159-166
Helical: 176-194
Helical: 200-217
Helical: 241-253
Helical: 257-265
Helical: 277-294
Helical: 335-364
Helical: 371-392
Helical: 462-481
Helical: 487-511
Helical: 519-533
Loop between two helices: 534-536
Helical: 537-548
Loop between two helices: 549-552
Helical: 553-571
Cytoplasmic: 572-869
PTM
N-glycosylated on several asparagine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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