CLDN6

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]
Full Name
Claudin 6
Function
Plays a major role in tight junction-specific obliteration of the intercellular space.

(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Cellular Location
Cell membrane; Tight junction
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-116
Helical: 117-137
Extracellular: 138-160
Helical: 161-181
Cytoplasmic: 182-220
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Anti-CLDN6 antibodies

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Human Anti-CLDN6 Recombinant Antibody (C0999) (CBMAB-C0999-LY)

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Target: CLDN6
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: C0999
Application*: E, F
Datasheet SDS

Mouse Anti-CLDN6 Recombinant Antibody (C11020) (CBMAB-C11020-LY)

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Target: CLDN6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C11020
Application*: P, WB, IF
Datasheet SDS

Mouse Anti-CLDN6 Recombinant Antibody (
8D7) (V2LY-0725-LY672)

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Target: CLDN6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8D7
Application*: E, F
Datasheet SDS

Human Anti-CLDN6 Recombinant Antibody (
6D4) (V2LY-0725-LY670)

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Target: CLDN6
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D4
Application*: E, F
Datasheet SDS

Mouse Anti-CLDN6 Recombinant Antibody (CBT2445) (V2LY-0625-LY1563)

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Target: CLDN6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2445
Application*: F
Datasheet SDS

Mouse Anti-CLDN6 Recombinant Antibody (CBXC-2625) (V2LY-1206-LY58)

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Target: CLDN6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-2625
Application*: WB
Datasheet SDS

Mouse Anti-CLDN6 Recombinant Antibody (CBXC-1122) (V2LY-1206-LY57)

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Target: CLDN6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-1122
Application*: E
Datasheet SDS

Mouse Anti-CLDN6 Recombinant Antibody (CBFYC-1908) (V2LY-1206-LY55)

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Target: CLDN6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1908
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-CLDN6 Recombinant Antibody (CBFYC-1907) (V2LY-1206-LY54)

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Target: CLDN6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-1907
Application*: IF, F
Datasheet SDS

Rabbit Anti-CLDN6 Recombinant Antibody (EG724) (CBMAB-EN878-LY)

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Target: CLDN6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG724
Application*: WB
Datasheet SDS

Human Anti-CLDN6 Recombinant Antibody (EG723) (CBMAB-EN877-LY)

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Target: CLDN6
Host: Human
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: EG723
Application*: F
Datasheet SDS

Mouse Anti-CLDN6 Recombinant Antibody (CBYY-C3020) (CBMAB-C4463-YY)

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Target: CLDN6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C3020
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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