Human Recombinant CLDN6, Nanodisc protein, Biotin Conjugated, His & AVI Tag (V2LY-0526-LY3211)

Name: Human Recombinant CLDN6, Nanodisc protein, Biotin Conjugated, His & AVI Tag
SKU: V2LY-0526-LY3211
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His & AVI Tag

Protein Construction

This product is Human Recombinant CLDN6, Nanodisc protein, Biotin Conjugated, His & AVI Tag consist of Amino Acid: 1-184 and predicts a molecular mass of 22.7 kDa.

Molecule Mass

22.7 kDa

Conjugates

Biotin

Sequence

Amino Acid: 1-184

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥75% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tirs, NaCl, Glycerol, DTT

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -70°C or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Claudin 6

Function

Plays a major role in tight junction-specific obliteration of the intercellular space.

(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.

Biological Process

Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central

Cellular Location

Cell membrane; Tight junction

Topology

Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-116
Helical: 117-137
Extracellular: 138-160
Helical: 161-181
Cytoplasmic: 182-220

Matsuzaki, J., Lele, S., Odunsi, K., & Tsuji, T. (2022). Identification of Claudin 6-specific HLA class I-and HLA class II-restricted T cell receptors for cellular immunotherapy in ovarian cancer. Oncoimmunology, 11(1), 2020983.

Du, H., Yang, X., Fan, J., & Du, X. (2021). Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation. Molecular Medicine Reports, 24(3), 1-9.

Gao, P., Peng, T., Cao, C., Lin, S., Wu, P., Huang, X., ... & Wu, P. (2021). Association of CLDN6 and CLDN10 With Immune Microenvironment in Ovarian Cancer: A Study of the Claudin Family. Frontiers in Genetics, 12.

Kojima, M., Sugimoto, K., Tanaka, M., Endo, Y., Kato, H., Honda, T., ... & Chiba, H. (2020). Prognostic significance of aberrant claudin-6 expression in endometrial cancer. Cancers, 12(10), 2748.

Kojima, M., Sugimoto, K., Kobayashi, M., Ichikawa-Tomikawa, N., Kashiwagi, K., Watanabe, T., ... & Chiba, H. (2021). Aberrant Claudin-6–Adhesion Signaling Promotes Endometrial Cancer Progression via Estrogen Receptor α. Molecular Cancer Research.

Kohmoto, T., Masuda, K., Shoda, K., Takahashi, R., Ujiro, S., Tange, S., ... & Imoto, I. (2020). Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer. Gastric Cancer, 23(3), 403-417.

Lewis, J. B., Bodine, J. S., Gassman, J. R., Muñoz, S. A., Milner, D. C., Dunaway, T. M., ... & Reynolds, P. R. (2018). Transgenic up-regulation of Claudin-6 decreases fine diesel particulate matter (DPM)-induced pulmonary inflammation. Environmental Science and Pollution Research, 25(18), 18179-18188.

Lin, D., Guo, Y., Li, Y., Ruan, Y., Zhang, M., Jin, X., ... & Quan, C. (2017). Bioinformatic analysis reveals potential properties of human Claudin-6 regulation and functions. Oncology reports, 38(2), 875-885.

Bekki, H., Yamamoto, H., Takizawa, K., Iwasaki, T., Otsuka, H., Yamada, Y., ... & Oda, Y. (2017). Claudin 6 expression is useful to distinguish myxofibrosarcomas from other myxoid soft tissue tumors. Pathology-Research and Practice, 213(6), 674-679.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CLDN6 (Detergent) protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY3208)

Human Recombinant CLDN6, Nanodisc protein, Fluorescent Conjugated, His Tag (CAT#: V2LY-0526-LY3210)

Human Recombinant CLDN6-VLP protein, Fluorescent Conjugated, (CAT#: V2LY-0526-LY3213)

Human Recombinant CLDN6-VLP protein (CAT#: V2LY-0526-LY3214)

Mouse Recombinant CLDN6 (Nanodisc) protein, His Tag (CAT#: V2LY-0526-LY8120)

Cynomolgus Recombinant CLDN6-VLP protein, Flag Tag (CAT#: V2LY-0526-LY1469)

Human Recombinant CLDN6 (Detergent) protein, His & Flag Tag (CAT#: V2LY-0526-LY3209)

Human Recombinant CLDN6, Nanodisc protein, His & Flag Tag (CAT#: V2LY-0526-LY3212)

Mouse Recombinant CLDN6-VLP protein, His & Flag Tag (CAT#: V2LY-0526-LY8121)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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